1,25-Dihydroxyvitamin D3 enhances the growth of tumors in athymic mice inoculated with receptor rich osteosarcoma cells.
1,25-Dihydroxyvitamin D3 enhances the growth of tumors in athymic mice inoculated with receptor rich osteosarcoma cells.
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1,25-二羟基维生素 D3 可增强接种富含受体骨肉瘤细胞的无胸腺小鼠的肿瘤生长。
DOI：
10.1016/s0006-291x(86)80318-7
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发表时间：
1986
影响因子：
3.1
通讯作者：
Haussler,MR
中科院分区：
文献类型：
--
作者：
Yamaoka,K;Marion,SL;Gallegos,A;Haussler,MR
我们检测了每天皮下注射12.5和25pmol1，25(OH)2D3对裸鼠皮下接种大鼠骨肉瘤细胞(ROS)和人黑色素瘤细胞所产生的肿瘤生长的影响。当小鼠接受富含1，25(OH)2D3受体的ROS17/2.8细胞后，两种剂量的1，25(OH)2D3都在3周后增加了血浆钙水平，并产生了显著的肿瘤重量增加。相比之下，1，25(OH)2D3对受体拷贝数低的G-361黑色素瘤细胞或受体缺失的ROS 24/1细胞的小鼠肿瘤重量没有一致的影响。因此，1，25(OH)2D3在体内以受体依赖的方式刺激肿瘤生长，而不是像预测的那样抑制1，25(OH)2D3存在下培养细胞的增殖抑制。
We tested the influence of daily subcutaneous injections of 12.5 and 25 pmol of 1,25-dihydroxyvitamin D3(1,25(OH)2D3) on the growth of tumors arising from intracutaneous inoculations of athymic nude mice with rat osteogenic sarcoma cells (ROS) and human melanoma cells. Both doses of 1,25(OH)2D3increased plasma calcium levels after 3 weeks and produced a striking enhancement in tumor weight when the mice received 1,25(OH)2D3receptor-rich ROS17/2.8 cells. In contrast, 1,25(OH)2D3caused no consistent effect on tumor weight in mice given G-361 melanoma cells with low receptor copy number or receptor deficient ROS 24/1 cells. Thus, 1,25(OH)2D3stimulated tumor growth in a receptor dependent fashion,invivo, instead of inhibiting it as predicted from the reduction of proliferation of cultured cells in the presence of 1,25(OH)2D3.