Left ventricular spherical dilation and regional contractile dysfunction in dogs with heart failure.
Left ventricular spherical dilation and regional contractile dysfunction in dogs with heart failure.
复制标题
心力衰竭犬的左心室球形扩张和局部收缩功能障碍。
DOI：
10.1152/ajpheart.1997.273.3.h1058
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Little,WC
中科院分区：
文献类型：
--
作者：
Suzuki,M;Cheng,CP;Ohte,N;Little,WC
在8只犬右心室快速起搏诱发充血性心力衰竭（CHF）过程中，连续测定了左心室短轴和长轴收缩功能及左心室结构的变化。起搏10天后，左室舒张末期容积（VED）未增加;然而，左室收缩末期压力-容积关系的斜率从7.4 +/- 2.6降至4.9 +/- 1.1 mmHg/ml左室每搏功-VED关系的斜率从78.4 ± 9.1下降到64.2 ± 7.2 mmHg（P < 0.05）。收缩末期压力-尺寸关系和每搏功面积-舒张末期尺寸关系在短轴上的斜率（即，前后和间隔-外侧）下降了30%（P < 0.05），而长轴的斜率（即，顶部-底部）关系不变（不显著）。起搏20天后，由于短轴选择性扩张7%，VED显著增加14%，LV整体收缩力进一步下降，短轴收缩抑制40%，长轴收缩抑制25%。30天后，终末孔的长轴尺寸也显著增加，短轴尺寸进一步增加。与CHF期间发生的球形扩张相反，正常动物的急性容量负荷产生对称的LV扩张。这些观察结果表明，不均匀收缩抑制启动球形舒张末期室扩张起搏诱导的CHF。
Left ventricular (LV) short- and long-axis contractile function and LV structural changes were serially measured in eight instrumented dogs during the development of congestive heart failure (CHF) induced by rapid right ventricular (RV) pacing. After 10 days of pacing, LV end-diastolic volume (VED) had not increased; however, the slope of LV end-systolic pressure-volume relation had decreased from 7.4 +/- 2.6 to 4.9 +/- 1.1 mmHg/ml (P < 0.05), and the slope of LV stroke work-VED relation had fallen from 78.4 +/- 9.1 to 64.2 +/- 7.2 mmHg (P < 0.05). The slopes of end-systolic pressure-dimension relation and the stroke work area-end-diastolic dimension relation in the short axes (i.e., anteroposterior and septal-lateral) had decreased by 30% (P < 0.05), whereas the slopes of the long-axis (i.e., apical-basal) relations were unchanged (not significant). After 20 days of pacing, VED had significantly increased by 14% due to selective dilation of the short axes by 7%, and LV global contractility had further declined with a 40% contractile depression in the short axes and a 25% contractile depression in the long axis. After 30 days, the long-axis dimension at end diastole was also significantly increased with a further increase in the short-axis dimensions. In contrast to the spherical dilation occurring during CHF, acute volume loading of normal animals produced symmetrical LV dilation. These observations suggest that heterogeneous contractile depression initiates the spherical end-diastolic chamber dilation in pacing-induced CHF.