ALTERNATIVE SPLICING OF STY, A NUCLEAR DUAL-SPECIFICITY KINASE
ALTERNATIVE SPLICING OF STY, A NUCLEAR DUAL-SPECIFICITY KINASE
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DOI：
10.1074/jbc.270.37.21524
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发表时间：
1995-09-15
影响因子：
4.8
通讯作者：
BELL, JC
中科院分区：
文献类型：
--
作者：
DUNCAN, PI;HOWELL, BW;BELL, JC
LAMMER激酶亚家族在整个进化过程中一直是保守的，其成员被认为在细胞生长和分化程序的调节中发挥重要作用。STY是一种鼠LAMMER激酶，其与PC12细胞分化的控制有关。多种转录物来源于Sty基因，并且它们的相对丰度是发育调节的。初级Sty转录物的选择性剪接产生编码全长催化活性（STY）和截短的激酶缺陷多肽的mRNA。STY及其截短的同种型STYT都位于细胞核中，并且能够异源二聚化。我们还证明了STY在哺乳动物细胞中作为双特异性激酶发挥作用。
The LAMMER subfamily of kinases has been conserved throughout evolution, and its members are thought to play important roles in the regulation of cellular growth and differentiation programs. STY is a murine LAMMER kinase which has been implicated in the control of PC12 cell differentiation. Multiple transcripts are derived from the Sty gene, and their relative abundance is developmentally regulated, Alternative splicing of the primary Sty transcript generates mRNAs encoding full-length catalytically active (STY) and truncated, kinase-deficient polypeptides. Both STY and its truncated isoform, STYT, are localized in the nucleus and are capable of heterodimerizing. We also demonstrate that STY functions as a dual specificity kinase in mammalian cells.