Comparison of local and systemic alendronate on distraction osteogenesis
Comparison of local and systemic alendronate on distraction osteogenesis
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DOI：
10.1016/j.ijom.2011.08.004
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发表时间：
2011-12-01
影响因子：
2.4
通讯作者：
Gumus, Cesur
中科院分区：
文献类型：
--
作者：
Kucuk, Dervishan;Ay, Sinan;Gumus, Cesur
本研究比较了全身和局部应用阿仑膦酸钠对兔下颌骨牵张成骨的影响。将30只新西兰白色家兔分为3组：10只家兔接受全身阿仑膦酸钠治疗; 9只接受局部阿仑膦酸钠治疗; 11只作为对照组。在5天的潜伏期后，通过定制的牵引器以0.8mm/天的速率进行牵引9天。在28天巩固期结束时处死动物。收集牵引的下颌骨，并通过X线平片、计算机断层扫描（CT）、双能X线吸收测定法（DEXA）和组织形态计量学进行评价。组织学上，比较全身和局部阿仑膦酸钠组，骨愈合参数无统计学显著差异，但各组均显示出统计学上优于对照组的上级效果（p < 0.05）。定量CT评估显示实验组和对照组之间的再生密度平均值存在显著差异。与对照组相比，实验组的平均骨密度显著增加。组织学、CT和DEXA分析表明，全身和局部使用阿仑膦酸钠可能有效地加速兔下颌骨牵张间隙中的新骨形成。
This study compared the effect of systemic and local administration of alendronate on distraction osteogenesis in rabbit mandibles. Thirty New Zealand white rabbits were allocated to 3 groups: 10 rabbits for systemic alendronate; 9 for local alendronate; and 11 as controls. After a 5 day latency period, distraction was performed at a rate of 0.8 mm/day for 9 days via a custom-made distractor. Animals were killed at the end of the consolidation period of 28 days. The distracted mandibles were harvested and evaluated by plain radiography, computed tomography (CT), dual energy X-ray absorptiometry (DEXA), and histomorphometry. Histologically, comparing the systemic and local alendronate groups, there were no statistically significant differences in the bone healing parameters, but each group showed a statistically superior effect over the control group (p < 0.05). Quantitative CT evaluation showed a significant difference mean in the density of the regeneration between experimental and control groups. There was a significant increase in mean bone mineral density in the experimental groups compared with the control group. Histologic, CT, and DEXA analysis demonstrated that using systemic and local alendronate may be effective in accelerating new bone formation in the distraction gap in rabbit mandibles.