Effects of Kamikihi-To, a traditional Chinese medicine, on behavioral changes induced by methyl-beta-carboline-3-carboxylate in mice and rats.
Effects of Kamikihi-To, a traditional Chinese medicine, on behavioral changes induced by methyl-beta-carboline-3-carboxylate in mice and rats.
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中药上木土对甲基-β-咔啉-3-羧酸酯诱导的小鼠和大鼠行为变化的影响。
DOI：
10.1254/jjp.75.391
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
Akira Yamashita
中科院分区：
文献类型：
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作者：
K. Nishizawa;Akira Yamashita
本实验观察了中药神起丸（KMK）对β-咔啉-3-羧酸甲酯（β-CCM）所致小鼠和大鼠行为学改变的影响。β-CCM是一种致焦虑的苯二氮卓类受体反向激动剂（3.0 mg/kg，在试验前1分钟静脉注射），可降低小鼠在新环境中的自主活动。此外，β-CCM（0.1 mg/kg，在试验前10分钟静脉注射）有助于抑制大鼠舔水冲突试验中由惩罚诱导的饮水行为。KMK（1.0和2.0 g/kg，p.o.在试验前1小时给药）拮抗了β-CCM处理的小鼠中减少的运动活动。KMK（2.0 g/kg，p.o.）也恢复了β-CCM治疗大鼠的饮酒行为抑制。KMK（2.0 g/kg，p.o.）在这些试验中，对未经β-CCM处理的小鼠和大鼠没有影响。这些发现表明，KMK对β-CCM诱导的行为变化具有保护作用。
The effects of Kamikihi-To (KMK), a traditional Chinese medicine, on behavioral changes induced by methyl-beta-carboline-3-carboxylate (beta-CCM) were evaluated in mice and rats. Beta-CCM, an anxiogenic benzodiazepine receptor inverse agonist (3.0 mg/kg, i.v. administered 1 min before the test), decreased the locomotor activity of mice in a novel environment. Furthermore, beta-CCM (0.1 mg/kg, i.v. administered 10 min before the test) facilitated the suppression of drinking behavior induced by punishment in the water lick conflict test in rats. KMK (1.0 and 2.0 g/kg, p.o. administered 1 hr before the test) antagonized the decreased locomotor activity in the beta-CCM-treated mice. KMK (2.0 g/kg, p.o.) also recovered the suppression of drinking behavior in the beta-CCM-treated rats. KMK (2.0 g/kg, p.o.) had no effect on beta-CCM-untreated mice and rats in these tests. These findings suggest that KMK has a protective effect against beta-CCM-induced behavioral changes.
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DOI：
--
发表时间：
2022
期刊：
影响因子：
--
作者：
河野彰代;乾千珠子;本間志保;脇坂 聡;Fujii M.;佐藤 元
通讯作者：
佐藤 元