Large serological survey showing cocirculation of Ebola and Marburg viruses in Gabonese bat populations, and a high seroprevalence of both viruses in Rousettus aegyptiacus
Large serological survey showing cocirculation of Ebola and Marburg viruses in Gabonese bat populations, and a high seroprevalence of both viruses in Rousettus aegyptiacus
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DOI：
10.1186/1471-2334-9-159
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发表时间：
2009-09-28
影响因子：
3.7
通讯作者：
Leroy, Eric
中科院分区：
文献类型：
--
作者：
Pourrut, Xavier;Souris, Marc;Leroy, Eric
背景：埃博拉病毒和马尔堡病毒引起人类高度致命的出血热。最近，已确定多种蝙蝠在加蓬和刚果共和国是扎伊尔埃博拉病毒（ZEBOV）的可能天然宿主，在加蓬和刚果民主共和国也是马尔堡病毒（MARV）的可能天然宿主。方法：我们对2003年至2008年在加蓬三个地区和刚果北部埃博拉疫区采集的至少9种2147只蝙蝠进行了ZEBOV和MARV特异性IgG抗体检测。结果：总体而言，在4%和1%的蝙蝠中分别检测到ZEBOV和MARV的IgG抗体。在6种蝙蝠（franqueti epoomops、Hypsignathus monstrosus、Myonycteris torquata、Micropteropus pusillus、Mops condylurus和Rousettus aegyptiacus）中均发现zebov特异性抗体，而在埃及Rousettus aegyptiacus和Hypsignathus monstrosus中均发现marv特异性抗体。洞穴内捕获的埃及伊蚊中marv特异性IgG的流行率明显高于其他地方。根据年龄或性别，患病率无显著差异。孕妇中zebov特异性IgG的流行率高于非孕妇。结论：这些发现证实ZEBOV和MARV在加蓬共传播，加蓬是唯一发现同时感染这两种病毒的蝙蝠的国家。两种病毒的IgG抗体仅在埃及罗塞塔斯蚊中检测到，这表明该蝙蝠物种可能参与了马尔堡病毒和埃博拉病毒的自然循环。在加蓬出现MARV表明存在首次人间暴发的潜在风险。应加强洞穴附近地区的疾病监测。
Background: Ebola and Marburg viruses cause highly lethal hemorrhagic fevers in humans. Recently, bats of multiple species have been identified as possible natural hosts of Zaire ebolavirus (ZEBOV) in Gabon and Republic of Congo, and also of marburgvirus (MARV) in Gabon and Democratic Republic of Congo.Methods: We tested 2147 bats belonging to at least nine species sampled between 2003 and 2008 in three regions of Gabon and in the Ebola epidemic region of north Congo for IgG antibodies specific for ZEBOV and MARV.Results: Overall, IgG antibodies to ZEBOV and MARV were found in 4% and 1% of bats, respectively. ZEBOV-specific antibodies were found in six bat species (Epomops franqueti, Hypsignathus monstrosus, Myonycteris torquata, Micropteropus pusillus, Mops condylurus and Rousettus aegyptiacus), while MARV-specific antibodies were only found in Rousettus aegyptiacus and Hypsignathus monstrosus. The prevalence of MARV-specific IgG was significantly higher in R. aegyptiacus members captured inside caves than elsewhere. No significant difference in prevalence was found according to age or gender. A higher prevalence of ZEBOV-specific IgG was found in pregnant females than in non pregnant females.Conclusion: These findings confirm that ZEBOV and MARV co-circulate in Gabon, the only country where bats infected by each virus have been found. IgG antibodies to both viruses were detected only in Rousettus aegyptiacus, suggesting that this bat species may be involved in the natural cycle of both Marburg and Ebola viruses. The presence of MARV in Gabon indicates a potential risk for a first human outbreak. Disease surveillance should be enhanced in areas near caves.