Parity and estrogen-administration alter affective behavior of ovariectomized rats.
Parity and estrogen-administration alter affective behavior of ovariectomized rats.
复制标题
产次和雌激素给药改变卵巢切除大鼠的情感行为。
DOI：
10.1016/j.physbeh.2007.09.002
复制
发表时间：
2008
影响因子：
2.9
通讯作者：
Frye,CherylA
中科院分区：
文献类型：
--
作者：
Walf,AliciaA;Frye,CherylA
Evidence from clinical and basic research studies demonstrates that estradiol (E2) reduces anxiety and/or depressive behavior; however, this effect is not observed in all studies. One factor that may mitigate differential responses to E2may be previous E2experience, i.e. parity. To investigate this, performance in tasks that are utilized to assess whether compounds, such as E2, can alter anxiety-like behavior (elevated plus maze) and have anti-depressant-like effects (forced swim test) were determined. Performance of ovariectomized (ovx), young (3–6 months old) rats that had never had a litter (nulliparous) was compared to that of those that had several litters in their lifetime (multiparous) following 48 h of oil vehicle or E2(10 μg) administration. We predicted that E2would decrease anxiety-like behavior and increase anti-depressant-like effects of ovx rats and that this pattern may be influenced by parity. Multiparous rats, irrespective of E2-priming, had increased open arm time compared to nulliparous rats. Administration of E2to ovx, nulliparous or multiparous rats decreased immobility in the forced swim test compared to vehicle-administration. Together, these data suggest that E2can alter affective behavior and rats with greater reproductive experience have decreased anxiety-like behavior in the elevated plus maze, irrespective of E2-priming.
