Effects of chronic cocaine use on physical health: A prospective study in a general population sample
Effects of chronic cocaine use on physical health: A prospective study in a general population sample
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DOI：
10.1016/s0376-8716(96)01285-9
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发表时间：
1996-12-02
影响因子：
4.2
通讯作者：
Kandel, DB
中科院分区：
文献类型：
--
作者：
Chen, K;Scheier, LM;Kandel, DB
很少有研究考察长期使用可卡因对普通人群身体健康的长期影响。目前的研究评估了20岁后期长期使用可卡因对30岁中期身体健康的影响，这是一个来自普通人群的纵向队列。身体健康的测量包括自我报告的健康状况，心血管，神经和躯体症状，以及过去一年内的住院或病假天数。因果分析仅限于男性，因为很少有女性大量使用可卡因，女性可卡因使用与身体健康之间的关系很少显着。在男性中，长期使用可卡因增加了身体健康问题，控制了以前的健康状况，目前使用可卡因，使用其他药物和社会人口特征。反过来，健康状况不佳也助长了可卡因的持续使用。基于可卡因使用模式（频率和慢性）的方差划分表明，长期使用者经历了最不利的后果，随后的身体健康。了解慢性可卡因使用如何影响广泛的身体功能的影响进行了讨论。
Few studies have examined long-term effects of chronic cocaine use on physical health in the general population. The current study assesses the effects of chronic cocaine use by the late twenties on physical health by the mid thirties in a longitudinal cohort from the general population. Measures of physical health included self-reported health status, cardiovascular, neurological, and somatic symptoms, and number of hospital or sick days within the last year. The causal analyses were restricted to males because few females used cocaine heavily and the relationships between females' cocaine use and physical health were rarely significant. Among males, chronic cocaine use increased physical health problems, controlling for prior health status, current cocaine use, use of other drugs and sociodemographic characteristics. In turn, poor health contributed to continued cocaine use. Variance partitioning based on cocaine use patterns (frequency and chronicity) indicated that chronic users experienced the most adverse consequences on subsequent physical health. Implications for understanding how chronic cocaine use affects a broad spectrum of physical functioning are discussed.