The convergent evolution of blue iris pigmentation in primates took distinct molecular paths.
The convergent evolution of blue iris pigmentation in primates took distinct molecular paths.
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DOI：
10.1002/ajpa.22280
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发表时间：
2013-07
影响因子：
2.8
通讯作者：
Przeworski, Molly
中科院分区：
文献类型：
--
作者：
Meyer, Wynn K.;Zhang, Sidi;Hayakawa, Sachiko;Imai, Hiroo;Przeworski, Molly
有多少条不同的分子路径导致相同的表型？解决这个问题的一种方法是研究趋同特征的遗传基础，这些特征可能在共同的选择压力下反复进化。我们研究了蓝色虹膜色素沉着的收敛表型，它独立地出现在四个灵长类动物谱系中：人类、蓝眼黑狐猴、日本猕猴和蜘蛛猴。在描述这些物种的表型时，我们发现每个物种的蓝眼睛亚集内的变异占据了CIE L*a*b*颜色空间的强烈重叠区域。然而，与日本猕猴和人类表现出不断变化不同的是，蓝眼黑狐猴及其姊妹物种(虹膜是棕色的)的表型占据了更多的聚集子空间。OCA2增强子的变异是蓝色虹膜和棕色虹膜患者表型差异的主要原因。在直系区，我们没有发现区分这两个狐猴物种的变异，也没有发现与日本猕猴的定量表型变异有关的变异。鉴于这些物种的蓝色虹膜表型与人类的高度相似，这一发现表明进化使用了不同的分子途径来达到相同的目的。Am J Phys Anthropol151：398-407,2013。
How many distinct molecular paths lead to the same phenotype? One approach to this question has been to examine the genetic basis of convergent traits, which likely evolved repeatedly under a shared selective pressure. We investigated the convergent phenotype of blue iris pigmentation, which has arisen independently in four primate lineages: humans, blue-eyed black lemurs, Japanese macaques, and spider monkeys. Characterizing the phenotype across these species, we found that the variation within the blue-eyed subsets of each species occupies strongly overlapping regions of CIE L*a*b* color space. Yet whereas Japanese macaques and humans display continuous variation, the phenotypes of blue-eyed black lemurs and their sister species (whose irises are brown) occupy more clustered subspaces. Variation in an enhancer of OCA2 is primarily responsible for the phenotypic difference between humans with blue and brown irises. In the orthologous region, we found no variant that distinguishes the two lemur species or associates with quantitative phenotypic variation in Japanese macaques. Given the high similarity between the blue iris phenotypes in these species and that in humans, this finding implies that evolution has used different molecular paths to reach the same end. Am J Phys Anthropol 151:398–407, 2013.© 2013 Wiley Periodicals, Inc.
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DOI：
10.1073/pnas.94.8.3817
发表时间：
1997-04-15
影响因子：
11.1
作者：
Chen, LB;DeVries, AL;Cheng, CHC
通讯作者：
Cheng, CHC
影响因子：
9.2
作者：
Chan, Yingguang Frank;Jones, Felicity C.;Tautz, Diethard
通讯作者：
Tautz, Diethard
影响因子：
9.2
作者：
Aminetzach, Yael T.;Srouji, John R.;Hoekstra, Hopi E.
通讯作者：
Hoekstra, Hopi E.
两个层面的进化：基因和形态。
影响因子：
9.8
作者：
Carroll, SB
通讯作者：
Carroll, SB
影响因子：
9.8
作者：
Duffy, David L.;Montgomery, Grant W.;Sturm, Richard A.
通讯作者：
Sturm, Richard A.