Bioactive Myrsinol Diterpenoids from the Roots of Euphorbia prolifera
Bioactive Myrsinol Diterpenoids from the Roots of Euphorbia prolifera
复制标题
来自大戟根的生物活性紫金醇二萜类化合物
DOI：
10.1021/np200591h
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发表时间：
2011-10-01
影响因子：
5.1
通讯作者：
Gui, Liping
中科院分区：
文献类型：
--
作者：
Xu, Jing;Guo, Yuanqiang;Gui, Liping
从大戟 (Euphorbia prolifera) 的根中分离出 10 种紫杉酚二萜、大戟素 A-J (1-10) 以及九种已知类似物 (11-19)。通过光谱数据分析（IR、ESIMS、HRESIMS、1D 和 2D NMR）阐明了它们的结构，并通过 X 射线晶体学证实了 1 的结构。二萜对 SH-SYSY 细胞中 MPP(+) 诱导的神经元细胞死亡具有神经保护作用。
Ten myrsinol diterpenes, euphorbiaproliferins A-J (1-10), along with nine known analogues (11-19) were isolated from the roots of Euphorbia prolifera. Their structures were elucidated by spectroscopic data analysis (IR, ESIMS, HRESIMS, 1D and 2D NMR), and the structure of 1 was confirmed by X-ray crystallography. The diterpenes showed neuroprotective effects against MPP(+)-induced neuronal cell death in SH-SYSY cells.