Accelerated hepatic fibrosis in patients with combined hereditary hemochromatosis and chronic hepatitis C infection
Accelerated hepatic fibrosis in patients with combined hereditary hemochromatosis and chronic hepatitis C infection
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DOI：
10.1016/s0168-8278(02)00018-1
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发表时间：
2002-05-01
影响因子：
25.7
通讯作者：
Bacon, BR
中科院分区：
文献类型：
--
作者：
Diwakaran, HH;Befeler, AS;Bacon, BR
目的：遗传性血色病（HH）和慢性丙型肝炎病毒（HCV）感染均可导致肝纤维化和肝硬化。铁超载和HCV可能对肝纤维化具有增强作用。这项研究确定，如果HH与HCV患者将出现肝纤维化/肝硬化在年轻的年龄和在较低的肝铁浓度相比，HH或HCVsolution.Methods：10例合并HCV和HH的患者进行了比较，13例单独HH和24例单独HCV。所有患者在肝活检时均为晚期纤维化/肝硬化。所有HH患者的C282 Y突变纯合子。结果：在与晚期纤维化/肝硬化，HH/HCV组的平均年龄显着低于HH组和HCV组。平均肝铁浓度较低的HH/HCV组合组相比，HH group.Conclusions：HH HCV患者目前与先进的纤维化/肝硬化在年轻的年龄和较低的肝铁浓度相比，HH患者没有HCV。这些发现支持了这样的概念，即HH诱导的铁超载和HCV的组合对肝纤维化具有增强作用。(C)2002年欧洲肝脏研究协会。由Elsevier Science B. V.出版，版权所有。
Background/Aims: Hereditary hemochromatosis (HH) and chronic hepatitis C virus (HCV) infection can both result in hepatic fibrosis and cirrhosis. It has been proposed that iron overload and HCV may have potentiating effects on hepatic fibrogenesis. This study determined if HH patients with HCV would present with hepatic fibrosis/cirrhosis at a younger age and at a lower hepatic iron concentration compared to patients with HH or HCV alone.Methods: Ten patients with combined HCV and HH were compared to 13 patients who had HH alone and 24 patients who had HCV alone. All patients had advanced fibrosis/cirrhosis on liver biopsy. All HH patients were homozygous for the C282Y mutation.Results: At presentation with advanced fibrosis/cirrhosis, the mean age of the HH/HCV group was significantly lower than that of the HH group and the HCV group. The mean hepatic iron concentration was lower in the combined HH/HCV group compared to that of the HH group.Conclusions: HH patients with HCV present with advanced fibrosis/cirrhosis at a younger age and at a lower hepatic iron concentration compared to HH patients without HCV. These findings support the concept that the combination of HH-induced iron overload and HCV has a potentiating effect on hepatic fibrogenesis.(C) 2002 European Association for the Study of the Liver. Published by Elsevier Science B.V. All rights reserved.