BRAIN MICRODIALYSIS STUDIES ON THE CONTROL OF DOPAMINE RELEASE AND METABOLISM INVIVO
BRAIN MICRODIALYSIS STUDIES ON THE CONTROL OF DOPAMINE RELEASE AND METABOLISM INVIVO
复制标题
DOI：
10.1016/0165-0270(90)90044-g
复制
发表时间：
1990-09-01
影响因子：
3
通讯作者：
BUTCHER, SP
中科院分区：
文献类型：
--
作者：
ARBUTHNOTT, GW;FAIRBROTHER, IS;BUTCHER, SP
本文研究了从脑组织中释放多巴胺的药物的作用。这项工作的大部分理论背景都是在体外脑切片实验中发展起来的，但是使用体内微透析，我们已经从体外实验中阐述和扩展了思想，并且能够直接比较5种不同操作的作用机制和释放多巴胺的来源。根据Justice et al.（1988）发表的神经末梢计算机模型，讨论酪胺、安非他明、缬草碱、乌巴因和钾的作用方式。这些数据可能适合这样一种解释，但它们可能与其他几种模型兼容。
This paper studies the actions of drugs known to release dopamine from brain tissue. Most of the theoretical background to this work has been developed in experiments on slices of brain in vitro but using in vivo microdialysis we have elaborated and extended the ideas from the in vitro experiments and been able to make a direct comparison of the mechanism of action and source of dopamine released by 5 different manipulations.The mode of action of tyramine, amphetamine, veratrine, ouabain and potassium is discussed in the light of the computer model of the nerve terminal published by Justice et al. (1988). The data may lend themselves to such an interpretation, but they could be compatible with several other models.