Males have larger skeletal size and bone mass than females, despite comparable body size
Males have larger skeletal size and bone mass than females, despite comparable body size
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DOI：
10.1359/jbmr.041005
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发表时间：
2005-03-01
影响因子：
6.2
通讯作者：
Cosman, F
中科院分区：
文献类型：
--
作者：
Nieves, JW;Formica, C;Cosman, F
骨折的性别差异可能与身体大小、骨大小、几何形状或密度有关。我们在身高和体重匹配的18岁男性（n = 36）和女性（n = 36）中进行了研究。尽管体型相当，男性在髋关节和胫骨远端有更大的BMC和BMD，胫骨皮质厚度更大。这可能会赋予更大的骨骼完整性，在males.Introduction：骨折的性别差异可能与身体的大小，骨的大小，几何形状，或密度。我们研究了这在男性（n = 36）和女性（n = 36，平均年龄= 18岁）配对匹配的身高和weight.Materials和方法：BMC，骨面积（BA），和BMD测量在脊柱和髋关节使用DXA。胫骨远端测量pQCT.Results和结论：男性有较高的瘦体重（92%）相比，女性（79%）。尽管男性的宽度更大，因此脊柱的BA更大，但未观察到椎体BMC或椎体高度的性别差异。男性股骨颈和全股骨的BMC和BA均高于男性（P < 0.02）。髋关节的几何变量，包括颈径和颈轴长度，男性也更大（p < 0.02）。男性的横截面惯性矩、安全系数和跌倒指数更大（所有p < 0.02）。与女性相比，男性胫骨BMC、体积BMD、皮质面积和厚度更大（p < 0.01），骨膜周长更大（p = 0.011），骨内膜周长更小（p = 0.058）。对瘦体重进行统计控制减少了性别差异，但男性仍有8%的髋关节BMD（p = 0.24）和5.3%的胫骨BMD（p = 0.05）。一个男性和女性的子集匹配（n = 14对）全髋关节BA。尽管BA相似，但该亚组中的男性在全髋关节的BMC和BMD仍高于女性（p < 0.05）。总之，尽管体型相当，男性在髋关节和胫骨远端的BMC和BMD高于女性，但在脊柱上则不然。BMC和BMD的差异与胫骨中更大的皮质厚度有关。我们的结论是，骨量和几何形状的差异赋予男性更大的骨骼完整性，这可能有助于降低男性的应力和骨质疏松性骨折的发生率。
Gender differences in fractures may be related to body size, bone size, geometry, or density. We studied this in 18-year-old males (n = 36) and females (n = 36) matched for height and weight. Despite comparable body size, males have greater BMC and BMD at the hip and distal tibia and greater tibial cortical thickness. This may confer greater skeletal integrity in males.Introduction: Gender differences in fractures may be related to body size, bone size, geometry, or density. We studied this in males (n = 36) and females (n = 36; mean age = 18 years) pair-matched for height and weight.Materials and Methods: BMC, bone area (BA), and BMD were measured in the spine and hip using DXA. Distal tibia was measured by pQCT.Results and Conclusions: Males had a higher lean mass (92%) compared with females (79%). No gender differences were observed for vertebral BMC or vertebral height, although males had greater width and thus BA at the spine. Males had greater BMC and BA at the femoral neck and total femur (P < 0.02). Geometric variables of the hip including neck diameter and neck-axis length were also greater in males (p < 0.02). There was greater cross-sectional moment of inertia, safety factor, and fall index in males (all p < 0.02). Males had greater tibial BMC, volumetric BMD, and cortical area and thickness compared with females (p < 0.01), with both greater periosteal circumference (p = 0.011) and smaller endosteal circumference (p = 0.058). Statistically controlling for lean mass reduced gender differences, but males still had 8% higher hip BMD (p = 0.24) and 5.3% higher total tibial BMD (p = 0.05). A subset of males and females were matched (n = 14 pairs) for total hip BA. Males in this subset still had greater BMC and BMD at the total hip (p < 0.05) than females, despite similar BA. In summary, despite comparable body size, males have greater BMC and BMD than females at the hip and distal tibia but not at the spine. Differences in BMC and BMD were related to greater cortical thickness in the tibia. We conclude that differences in bone mass and geometry confer greater skeletal integrity in males, which may contribute to the lower incidence of stress and osteoporotic fractures in males.