Cell and organ printing turns 15: Diverse research to commercial transitions
Cell and organ printing turns 15: Diverse research to commercial transitions
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DOI：
10.1557/mrs.2013.209
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发表时间：
2013-10
期刊：
影响因子：
5
通讯作者：
B. Ringeisen;R. Pirlo;Peter K. Wu;T. Boland;Yong Huang;Wei Sun;Q. Hamid;D. Chrisey
中科院分区：
文献类型：
--
作者：
B. Ringeisen;R. Pirlo;Peter K. Wu;T. Boland;Yong Huang;Wei Sun;Q. Hamid;D. Chrisey
15年前，细胞和器官打印领域开始于几个研究小组，他们希望将新开发的直写工具应用于活细胞。初步实验证明了细胞在沉积后的活性和功能。最近，人们开始认真研究创造三维细胞结构，模拟自然组织的异质结构和功能。几家公司现在正在营销细胞打印机，扩大了对更广泛的科学家群体的接触，并加快了开发步伐。这篇文章描述了过去15年的研究，展示了一些最复杂的工作的例子，比较了该领域使用的方法和工具，并预测了在不太遥远的未来将出现的产品。
Fifteen years ago, the field of cell and organ printing began with a few research groups looking to take newly developed direct-write tools and apply them to living cells. Initial experiments demonstrated cell viability and functionality post-deposition. Recently, research has begun in earnest to create three-dimensional cellular constructs that mimic both the heterogeneous structure and function of natural tissue. Several companies are now marketing cell printers, expanding access to a wider group of scientists and accelerating the pace of development. This article describes the past decade and a half of research by showing examples of some of the most sophisticated work, comparing the approaches and tools used in the field, and predicting the products that will arrive in the not too distant future.