Fundamentals of cancer metabolism.
Fundamentals of cancer metabolism.
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DOI：
10.1126/sciadv.1600200
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发表时间：
2016-05
期刊：
影响因子：
13.6
通讯作者：
Chandel NS
中科院分区：
文献类型：
--
作者：
DeBerardinis RJ;Chandel NS
研究人员提供了一个概念框架，以了解癌症代谢的基础知识。肿瘤重新编程营养获取和代谢的途径，以满足恶性细胞的生物能量、生物合成和氧化还原需求。这些重新编程的活动现在被认为是癌症的标志，最近的工作发现了肿瘤细胞激活的特定途径的显着灵活性，以支持这些关键功能。从这个角度来看，我们提供了一个概念框架，以了解如何和为什么代谢重编程发生在肿瘤细胞中，以及改变代谢与肿瘤发生和转移的机制。理解这些概念将逐步支持治疗人类癌症的新策略的发展。
Researchers provide a conceptual framework to understand current knowledge of the fundamentals of cancer metabolism. Tumors reprogram pathways of nutrient acquisition and metabolism to meet the bioenergetic, biosynthetic, and redox demands of malignant cells. These reprogrammed activities are now recognized as hallmarks of cancer, and recent work has uncovered remarkable flexibility in the specific pathways activated by tumor cells to support these key functions. In this perspective, we provide a conceptual framework to understand how and why metabolic reprogramming occurs in tumor cells, and the mechanisms linking altered metabolism to tumorigenesis and metastasis. Understanding these concepts will progressively support the development of new strategies to treat human cancer.