The auditory-evoked N2 and P3 components in the stop-signal task: Indices of inhibition, response-conflict or error-detection?
The auditory-evoked N2 and P3 components in the stop-signal task: Indices of inhibition, response-conflict or error-detection?
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DOI：
10.1016/j.bandc.2006.03.011
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发表时间：
2006-11-01
影响因子：
2.5
通讯作者：
Barry, Robert J.
中科院分区：
文献类型：
--
作者：
Dimoska, Aneta;Johnstone, Stuart J.;Barry, Robert J.
在停止信号任务中，N2和P3成分分别与反应抑制有关，最近，N2被认为与反应冲突的检测有关。为了将反应抑制活动从早期感觉加工中分离出来，本研究将停止信号的处理与任务无关的音调的处理进行了比较，受试者被指示忽略后者。相对于忽略信号的试验，停止信号在失败的试验中引起了更大的N2，在成功的试验中引起了更大的P3，可能分别反映了与失败和成功停车相关的活动。快速和慢反应时间（RT）组之间的erp也被检查，因为假设在反映这一过程的成分中表现出更大的抑制激活来阻止更快的反应。成功停止P3显示出预期的效果（快速RT组的整体幅度大于慢速RT组），支持其与持续反应停止的关联。相比之下，慢速RT组的N2大于快速RT组，并且与反应冲突假说的预测相反，成功停止N2和反应锁定错误负性（Ne）在头皮分布上存在差异。这些发现表明，成功停止N2可能更好地解释为反应控制或选择的蓄意形式，慢速RT组将其作为增加成功停止可能性的手段。最后，刺激和反应锁定的erp的比较显示，停止失败的N2和P3似乎反映了与错误相关的活动，在反应锁定的Ne和错误阳性（Pe）中观察得最好。总之，这些发现表明，成功停止的N2和P3反映了依赖于性能策略的反应控制的功能不同方面，而失败停止的N2和P3反映了与错误相关的活动。(c) 2006爱思唯尔公司版权所有。
The N2 and P3 components have been separately associated with response inhibition in the stop-signal task, and more recently, the N2 has been implicated in the detection of response-conflict. To isolate response inhibition activity from early sensory processing, the present study compared processing of the stop-signal with that of a task-irrelevant tone, which subjects were instructed to ignore. Stop-signals elicited a larger N2 on failed-stop trials and a larger P3 on successful-stop trials, relative to ignore-signal trials, likely reflecting activity related to failed and successful stopping, respectively. ERPs between fast and slow reaction-time (RT) groups were also examined as it was hypothesised that greater inhibitory activation to stop faster responses would manifest in the component reflecting this process. Successful-stop P3 showed the anticipated effect (globally larger amplitude in the fast than slow RT group), supporting its association with the stopping of an ongoing response. In contrast, N2 was larger in the slow than fast RT group, and in contrast to the predictions of the response-conflict hypothesis, successful-stop N2 and the response-locked error-negativity (Ne) differed in scalp distribution. These findings indicate that the successful-stop N2 may be better explained as a deliberate form of response control or selection, which the slow RT group employed as a means of increasing the likelihood of a successful-stop. Finally, a comparison of stimulus and response-locked ERPs revealed that the failed-stop N2 and P3 appeared to reflect error-related activity, best observed in the response-locked Ne and error-positivity (Pe). Together these findings indicate that the successful-stop N2 and P3 reflect functionally distinct aspects of response control that are dependent upon performance strategies, while failed-stop N2 and P3 reflect error-related activity. (c) 2006 Elsevier Inc. All rights reserved.