CHEMICAL IDENTITY OF THE ACRASIN OF THE CELLULAR SLIME-MOLD POLYSPHONDYLIUM-VIOLACEUM
CHEMICAL IDENTITY OF THE ACRASIN OF THE CELLULAR SLIME-MOLD POLYSPHONDYLIUM-VIOLACEUM
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DOI：
10.1073/pnas.79.23.7376
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发表时间：
1982-01-01
期刊：
影响因子：
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通讯作者：
BONNER, JT
中科院分区：
文献类型：
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作者：
SHIMOMURA, O;SUTHERS, HLB;BONNER, JT
鉴定了紫色假单胞菌的聚集化学引诱物（或acrasin），紫色假单胞菌是一种不对cAMP产生化学反应的细胞黏菌。从聚集性阿米巴原虫中提取纯化，并对其进行氨基酸组成、红外光谱和质谱分析。活性分子是N-丙酰基-γ- L-谷氨酰-L-鸟氨酸-δ-内酰胺乙酯（MW 327），命名为glorin。该化合物是合成的，并显示出正常的趋化活性与变形虫的紫色变形杆菌。
The aggregation chemoattractant (or acrasin) of P. violaceum, a species of cellular slime mold that does not respond chemotactically to cAMP, was identified. It was extracted and purified from aggregating amoebae, then analyzed for amino acid composition and by IR and mass spectrometry. The active molecule is N-propionyl-.gamma.-L-glutamyl-L-ornithine-.delta.-lactam ethyl ester (MW 327), which was named glorin. The compound was synthesized and shows normal chemotactic activity with the amoebae of P. violaceum.