Serum Metabolic Profile Alteration Reveals Response to Platinum-Based Combination Chemotherapy for Lung Cancer: Sensitive Patients Distinguished from Insensitive ones.
Serum Metabolic Profile Alteration Reveals Response to Platinum-Based Combination Chemotherapy for Lung Cancer: Sensitive Patients Distinguished from Insensitive ones.
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血清代谢谱的改变揭示了对肺癌铂类联合化疗的反应：敏感患者与不敏感患者的区别
DOI：
10.1038/s41598-017-16085-y
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发表时间：
2017-12-13
影响因子：
4.6
通讯作者：
Cui Y
中科院分区：
文献类型：
--
作者：
Xu S;Zhou Y;Geng H;Song D;Tang J;Zhu X;Yu D;Hu S;Cui Y
由于临床症状有限，大多数肺癌在相当晚期才被诊断出来。以铂为基础的化疗，无论是单一方案还是联合放疗，都是对患者的主要建议之一。鉴于化疗药物的毒性，早期评估化疗的有效性对于制定更好的治疗计划至关重要。药物的疗效可以反映在全身代谢特征上，但对其了解较少。本研究采用模式识别结合核磁共振技术，研究顺铂联合吉西他滨、长春瑞滨和多西他赛三种常用铂基联合化疗方案对血清代谢的影响。根据患者对治疗的反应分为敏感亚组和不敏感亚组。我们发现不敏感的受试者可以从敏感的受试者中识别出来，葡萄糖和牛磺酸上调，血清中丙氨酸和乳酸浓度降低。肺癌联合化疗伴随着能量代谢、磷脂酰胆碱生物合成等多种代谢途径的紊乱，使得治疗患者与未治疗患者存在轻微的区别。患者的血清代谢谱显示了他们对铂基联合化疗反应的潜在指标。
Most lung cancers are diagnosed at fairly advanced stages due to limited clinical symptoms. Platinum-based chemotherapy, either as single regimen or in combination with radiation, is one of the major recommendations for the patients. Earlier evaluation of the effectiveness of the chemotherapies is critical for developing better treatment plan given the toxicity of the chemotherapeutic reagents. Drug efficacy could be reflected in the systemic metabolism characteristics though knowledge about which remains scarce. In this study, serum metabolism influence of three types of commonly used platinum-based combination chemotherapy regimens, namely cisplatin with gemcitabine, vinorelbine or docetaxel, were studied using pattern recognition coupled with nuclear magnetic resonance techniques. The treated patients were divided into sensitive or insensitive subgroups according to their response to the treatments. We found that insensitive subjects can be identified from the sensitive ones with up-regulation of glucose and taurine but reduced alanine and lactate concentrations in serum. The combination chemotherapy of lung cancer is accompanied by disturbances of multiple metabolic pathways such as energy metabolism, phosphatidylcholine biosynthesis, so that the treated patients were marginally discriminated from the untreated. Serum metabolic profile of patients shows potential as an indicator of their response to platinum-based combination chemotherapy.
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影响因子：
3.7
作者：
Lodi A;Ronen SM
通讯作者：
Ronen SM
DOI：
10.1056/nejmoa1214271
发表时间：
2013-03-21
期刊：
The New England journal of medicine
影响因子：
--
作者：
Friboulet L;Olaussen KA;Pignon JP;Shepherd FA;Tsao MS;Graziano S;Kratzke R;Douillard JY;Seymour L;Pirker R;Filipits M;André F;Solary E;Ponsonnailles F;Robin A;Stoclin A;Dorvault N;Commo F;Adam J;Vanhecke E;Saulnier P;Thomale J;Le Chevalier T;Dunant A;Rousseau V;Le Teuff G;Brambilla E;Soria JC
通讯作者：
Soria JC
影响因子：
9.7
作者：
Jobard, Elodie;Pontoizeau, Clement;Tredan, Olivier
通讯作者：
Tredan, Olivier
MiR-199a-5p 与恶性肿瘤呈负相关，并通过靶向肝癌中的己糖激酶 2 来调节糖酵解和乳酸的产生
影响因子：
13.5
作者：
Guo, Weijie;Qiu, Zhaoping;He, Xianghuo
通讯作者：
He, Xianghuo
DOI：
10.1016/j.chemolab.2014.04.014
发表时间：
2014-07-15
影响因子：
3.9
作者：
Li, Ya-Qiong;Liu, Yi-Fei;Cui, Yan-Fang
通讯作者：
Cui, Yan-Fang