Anti-proliferative properties of prenylated flavonoids from hops (Humulus lupulus L.) in human prostate cancer cell lines
Anti-proliferative properties of prenylated flavonoids from hops (Humulus lupulus L.) in human prostate cancer cell lines
复制标题
DOI：
10.1016/j.phymed.2006.01.001
复制
发表时间：
2006-11-01
期刊：
影响因子：
7.9
通讯作者：
De Keukeleire, D.
中科院分区：
文献类型：
--
作者：
Delmulle, L.;Bellahcene, A.;De Keukeleire, D.
在体外研究了酒花（Humulus lupulus L.）中存在的查尔酮黄腐酚(X)和去甲基黄腐酚（DMX），以及相应的黄酮异黄腐酚（IX，来自X）、8-烯丙基柚皮素（8-PN，来自DMX）和6-烯丙基柚皮素（6-PN，来自DMX）对人前列腺癌细胞PC-3和DU145的抗增殖活性。X对DU145和PC-3的IC50值分别为12.3 +/- 1.1 μ M和13.2 +/- 1.1 μ M，是抑制细胞系生长最有效的化合物。6-PN是第二活跃的生长抑制剂，特别是在PC-3细胞中（IC50为18.4 +/- 1.2 μ M）。8-PN是一种高效的植物雌激素，对PC-3和DU145表现出明显的抗增殖作用（IC50分别为33.5 +/- 1.0和43.1 +/- 1.2 μ M）， IX具有类似的活性（PC-3和DU145的IC50分别为45.2 +/- 1.1 μ M和47.4 +/- 1.1 μ M）。DMX是活性最低的化合物。首次在体外实验中证实了啤酒花烯酰化类黄酮能有效抑制前列腺癌细胞的增殖。(c) 2006 Elsevier GmbH版权所有。
Chalcones xanthohumol (X) and desmethylxanthohumol (DMX), present in hops (Humulus lupulus L.), and the corresponding flavanones isoxanthohumol (IX, from X), 8-prenylnaringenin (8-PN, from DMX), and 6-prenylnaringenin (6-PN, from DMX), have been examined in vitro for their anti-proliferative activity on human prostate cancer cells PC-3 and DU145. X proved to be the most active compound in inhibiting the growth of the cell lines with IC50 values of 12.3 +/- 1.1 mu M for DU145 and 13.2 +/- 1.1 mu M for PC-3. 6-PN was the second most active growth inhibitor, particularly in PC-3 cells (IC50 of 18.4 +/- 1.2 mu M). 8-PN, a highly potent phytoestrogen, exhibited pronounced anti-proliferative effects on PC-3 and DU145 (IC50 of 33.5 +/- 1.0 and 43.1 +/- 1.2 mu M, respectively), and IX gave comparable activities (IC50 of 45.2 +/- 1.1 mu M for PC-3 and 47.4 +/- 1.1 mu M for DU145). DMX was the least active compound. It was evidenced for the first time that this family of prenylated flavonoids from hops effectively inhibits proliferation of prostate cancer cells in vitro. (c) 2006 Elsevier GmbH. All rights reserved.