MHCPred: a server for quantitative prediction of peptide-MHC binding
MHCPred: a server for quantitative prediction of peptide-MHC binding
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DOI：
10.1093/nar/gkg510
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发表时间：
2003-07-01
影响因子：
14.9
通讯作者：
Flower, DR
中科院分区：
文献类型：
--
作者：
Guan, PP;Doytchinova, IA;Flower, DR
准确的T细胞表位预测是计算疫苗学的主要目标。作为对免疫学和疫苗学社区的服务，我们已经实现了，作为万维网上的服务器，基于偏最小二乘法的多变量统计方法来定量预测肽与主要组织相容性复合物（MHC）的结合，这是适应性细胞免疫中抗原呈递途径的关键检查点。MHCPred对两种I类等位基因都实施了稳健的统计模型（HLA-A*0101、HLA-A *0201、HLA-A *0202、HLA-A*0203、HLA-A*0206、HLA-A*0301、HLA-A*1101、HLA-A*3301、HLA-A*6801、HLA-A*6802和HLA-B*3501）和II类等位基因（HLA-DRB*0401，HLA-DRB*0401和HLA-DRB*0701）。MHCPred可从URL：http://www.jenner.ac.uk/MHCPred获得。
Accurate T-cell epitope prediction is a principal objective of computational vaccinology. As a service to the immunology and vaccinology communities at large, we have implemented, as a server on the World Wide Web, a partial least squares-based multivariate statistical approach to the quantitative prediction of peptide binding to major histocom- patibility complexes (MHC), the key checkpoint on the antigen presentation pathway within adaptive cellular immunity. MHCPred implements robust statistical models for both Class I alleles (HLA-A*0101, HLA-A*0201, HLA-A*0202, HLA-A*0203, HLA-A*0206, HLA-A*0301, HLA-A*1101, HLA-A*3301, HLA-A*6801, HLA-A*6802 and HLA-B*3501) and Class II alleles (HLA-DRB*0401, HLA-DRB*0401 and HLA-DRB*0701). MHCPred is available from the URL: http://www.jenner.ac.uk/MHCPred.