Supramolecular Phosphatases Formed by the Self-Assembly of Bis(Zn2+-cyclen) Complex, Copper(II), and Barbital Derivatives in Water (Cyclen = 1,4,7,10-Tetraazacyclododecane)
Supramolecular Phosphatases Formed by the Self-Assembly of Bis(Zn2+-cyclen) Complex, Copper(II), and Barbital Derivatives in Water (Cyclen = 1,4,7,10-Tetraazacyclododecane)
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双(Zn2 -cyclen) 络合物、铜(II) 和巴比妥衍生物在水中自组装形成的超分子磷酸酶（Cyclen = 1,4,7,10-四氮杂环十二烷）
DOI：
10.1002/asia.201402513
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
and Shin Aoki,
中科院分区：
文献类型：
--
作者：
Mohd Zulkefeli;Yosuke Hisamatsu;Asami Suzuki;Yuya Miyazawa;Motoo Shiro;and Shin Aoki,
在我们以前的论文中，我们报道了一个带有2，2‘-联吡啶基键(Zn2L1)、三聚氰酸(CA)和Cu2+离子的二聚锌配合物在水溶液中自动组装形成4：4：4的配合物3，该配合物在中性pH条件下选择性地催化磷酸一(4-硝基苯基)酯(MNP)的水解。本文报道了用巴比妥钠(BAR)代替CA与锌和铜的自组装，使这些组分发生2：2：2的络合反应，而不是4：4：4的络合物，形成超分子络合物6 a。结果表明，与3类似，6 a也加速了MnP的水解率。此外，受6- a晶体结构的启发，我们制备了侧链上含有官能团的巴比妥单元体，试图合成在Cu2(μ-OH)2催化核附近具有官能团的超分子磷酸酶，从而模拟碱性磷酸酶(AP)的催化中心。
In our previous paper, we reported that a dimeric Zn2+complex with a 2,2′‐bipyridyl linker (Zn2L1), cyanuric acid (CA), and a Cu2+ion automatically assemble in aqueous solution to form 4:4:4 complex3, which selectively catalyzes the hydrolysis of mono(4‐nitrophenyl)phosphate (MNP) at neutral pH. Herein, we report that the use of barbital (Bar) instead of CA for the self‐assembly with Zn2L1and Cu2+induces 2:2:2 complexation of these components, and not the 4:4:4 complex, to form supramolecular complex6 a, the structure and equilibrium characteristics of which were studied by analytical and physical measurements. The finding show that6 aalso accelerates the hydrolysis of MNP, similarly to3. Moreover, inspired by the crystal structure of6 a, we prepared barbital units that contain functional groups on their side chains in an attempt to produce supramolecular phosphatases that possess functional groups near the Cu2(μ‐OH)2catalytic core so as to mimic the catalytic center of alkaline phosphatase (AP).