Physiology of the fetal circulation
Physiology of the fetal circulation
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DOI：
10.1016/j.siny.2005.08.007
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发表时间：
2005-12-01
影响因子：
3
通讯作者：
Kiserud, T
中科院分区：
文献类型：
--
作者：
Kiserud, T
我们对胎儿循环生理学的理解是基于实验动物数据的，这仍然是对发育机制的新见解的重要来源。越来越多的人体研究对人体生理学进行了研究，其结果与动物研究的结果相似，但又不完全相同。是时候认识到这些差异，把我们的临床方法更多地建立在人体生理学的基础上了。因此，本文将重点介绍主要通过人体研究发现的分布模式和适应机制。这些包括心输出量、肺和胎盘循环、胎儿脑和肝脏、静脉回流到心脏和胎儿分流（静脉导管、卵形孔和动脉导管）。胎盘妥协诱导了一套适应和补偿机制，反映了发育循环的可塑性，具有短期和长期的影响。其中一些方面已经成为当今临床生理学的一部分，对监测和治疗产生了影响。(c) 2005 Elsevier Ltd版权所有。
Our understanding of fetal circulatory physiology is based on experimental animal data, and this continues to be an important source of new insight into developmental mechanisms. A growing number of human studies have investigated the human physiology, with results that are similar but not identical to those from animal studies. It is time to appreciate these differences and base more of our clinical approach on human physiology. Accordingly, the present review focuses on distributional patterns and adaptational mechanisms that were mainly discovered by human studies. These include cardiac output, pulmonary and placental circulation, fetal brain and liver, venous return to the heart, and the fetal shunts (ductus venosus, foramen ovate and ductus arteriosus). Placental compromise induces a set of adaptational and compensational mechanisms reflecting the plasticity of the developing circulation, with both short- and long-term implications. Some of these aspects have become part of the clinical physiology of today with consequences for surveillance and treatment. (c) 2005 Elsevier Ltd. All rights reserved.