Self-Expanding Anchors for Stabilizing Percutaneously Implanted Microdevices in Biological Tissues.
Self-Expanding Anchors for Stabilizing Percutaneously Implanted Microdevices in Biological Tissues.
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DOI：
10.3390/mi12040404
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发表时间：
2021-04-06
期刊：
影响因子：
3.4
通讯作者：
Jonas O
中科院分区：
文献类型：
--
作者：
Bhagavatula S;Thompson D;Dominas C;Haider I;Jonas O
经皮植入的微型设备，例如基准标记、微型传感器和药物输送设备，在诊断和治疗多种疾病中具有重要且不断扩大的作用。然而，需要开发和评估锚定方法，以确保这些微型装置保持安全而不会移位，因为即使组织内的最小迁移也可能导致微型装置功能丧失或临床并发症。在这里，我们描述了两种由生物相容性材料制成的锚定方法：（1）自膨胀镍钛诺网锚和（2）包含在柔韧网内的自膨胀水凝胶颗粒。我们将这些锚定物集成到现有的药物筛选微型设备中，并通过实验测量将它们从不同组织中移出所需的力。我们报告了镍钛诺锚定微型器件的相似位移力为 738 ± 37、707 ± 40、688 ± 29 和 520 ± 28 mN，而水凝胶锚定微型器件在肝、肾、脂肪和脂肪组织中的位移力为 735 ± 98、702 ± 46、457 ± 47 和 459 ± 39 mN。分别与非锚定微装置的 13 ± 2、15 ± 3、15 ± 2 和 15 ± 3 mN 相比显着更高（所有组织中 p < 0.001）。锚固方法使所有组织的抗移位能力增加了 30-50 倍，不会增加插入所需的针规格，并且与经皮植入和移除兼容。这些结果表明锚定显着提高了微器件的稳定性，并应降低各种生物组织中的迁移风险。
Percutaneously implanted miniaturized devices such as fiducial markers, miniaturized sensors, and drug delivery devices have an important and expanding role in diagnosing and treating a variety of diseases. However, there is a need to develop and evaluate anchoring methods to ensure that these microdevices remain secure without dislodgement, as even minimal migration within tissues could result in loss of microdevice functionality or clinical complications. Here we describe two anchoring methods made from biocompatible materials: (1) a self-expanding nitinol mesh anchor and (2) self-expanding hydrogel particles contained within pliable netting. We integrate these anchors into existing drug-screening microdevices and experimentally measure forces required to dislodge them from varying tissues. We report similar dislodgement forces of 738 ± 37, 707 ± 40, 688 ± 29, and 520 ± 28 mN for nitinol-anchored microdevices, and 735 ± 98, 702 ± 46, 457 ± 47, and 459 ± 39 mN for hydrogel-anchored microdevices in liver, kidney, fat, and muscle tissues, respectively—significantly higher compared with 13 ± 2, 15 ± 3, 15 ± 2, and 15 ± 3 mN for non-anchored microdevices (p < 0.001 in all tissues). The anchoring methods increased resistance to dislodgement by a factor of 30–50× in all tissues, did not increase the required needle gauge for insertion, and were compatible with percutaneous implantation and removal. These results indicate that anchoring significantly improves microdevice stability and should reduce migration risk in a variety of biological tissues.
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影响因子：
2.6
作者：
Pinkney, David M.;Mychajlowycz, Mirek;Shah, Biren A.
通讯作者：
Shah, Biren A.
DOI：
10.1158/1078-0432.ccr-15-2722
发表时间：
2016-12-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Jonas O;Oudin MJ;Kosciuk T;Whitman M;Gertler FB;Cima MJ;Flaherty KT;Langer R
通讯作者：
Langer R
影响因子：
2.1
作者：
Ankem, MK;DeCarvalho, VS;Weiss, RE
通讯作者：
Weiss, RE
影响因子：
1.9
作者：
Zhu, Alan X.;Wallner, Kent E.;Foster, Gary P.
通讯作者：
Foster, Gary P.
DOI：
10.1016/j.jvir.2014.01.004
发表时间：
2014-05-01
影响因子：
2.9
作者：
Trumm, Christoph G.;Haeussbler, Sophia M.;Hoffmann, Ralf-Thorsten
通讯作者：
Hoffmann, Ralf-Thorsten