Neural substrates for sexual preference and motivation in the female and male rat
Neural substrates for sexual preference and motivation in the female and male rat
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DOI：
10.1196/annals.1417.009
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发表时间：
2008-01-01
期刊：
影响因子：
--
通讯作者：
Sakuma, Yasuo
中科院分区：
文献类型：
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作者：
Sakuma, Yasuo
啮齿类动物通过嗅觉线索来识别交配伙伴。当身体接触受到阻碍时，发情期的雌性老鼠会花更长的时间嗅性活跃的雄性老鼠的气味。性活跃的雄性会被雌性的气味所吸引。当受试者切除性腺后，对任一性别的偏好就会消失，通过补充雌激素或睾酮可以逆转这种效应。因此，循环中的性类固醇决定了两性的气味偏好。无论男女，嗅觉信号都会到达基底前脑。该区域包括视前区 (POA)、无名质和伏隔核，这些结构具有雌激素受体阳性神经元。在发情雌性中，POA 中的神经元在交配前动机行为期间被激活。该区域的损伤实际上消除了性偏好并削弱了性动机。雌性在发情期运动的增加，显然取决于雌激素敏感的 POA 投射到中脑运动区域，被认为体现了性动机的增强。
Rodents identify a mating partner by using olfactory cues. Female rats in estrus spend a longer time sniffing odors of sexually active males when physical contacts are hampered. Sexually active males are attracted by odors of receptive females. The preference in either sex disappears when the subjects axe gonadectomized, an effect reversible by supplement with estrogen or testosterone. Thus, circulating sex steroids determine the odor preference in both sexes. In both sexes, olfactory cues get to the basal forebrain; this area includes the preoptic area (POA), substantia innominata and accumbens, structures with estrogen receptor-positive neurons. In estrous females, neurons in the POA are activated during precopulatory motivational behavior. Lesion in this area practically eliminates sexual preference and diminishes the motivation. An increase in locomotion in females in estrus, which apparently depends on estrogen-sensitive POA projections to the midbrain locomotor region, has been considered to embody enhanced sexual motivation.