Starch–acrylics graft copolymers and blends: Synthesis, characterization, and applications as matrix for drug delivery
Starch–acrylics graft copolymers and blends: Synthesis, characterization, and applications as matrix for drug delivery
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DOI：
10.1002/app.30870
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发表时间：
2009-12
影响因子：
3
通讯作者：
M. M. Shaikh-M.;S. V. Lonikar
中科院分区：
文献类型：
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作者：
M. M. Shaikh-M.;S. V. Lonikar
采用稀土离子引发法制备了一系列单体含量不同的丙烯酸酯单体-淀粉接枝共聚物。用红外光谱和13C-核磁共振对接枝共聚物进行了表征。结果表明，随着单体浓度[丙烯酸(AA)、甲基丙烯酸(MA)和甲基丙烯酸甲酯(MMA)]浓度的增加，所有接枝共聚物中的接枝百分数增加，接枝效率最初增加，但随着单体浓度的进一步增加略有下降(除MMA外)。用分光光度法研究了对乙酰氨基酚作为模型药物从接枝共聚物及其共混物中的释放速率。在pH为1.2的磷酸盐缓冲溶液中，St-g-PAA-和St-g-PMA-接枝共聚物在前3h内对扑热息痛的释放不明显，这归因于在较低pH下通过氢键对基质的致密和稳定。在pH为7.4时，释药速率随添加量的增加而降低。含有聚甲基丙烯酸甲酯(PMMA)的片剂在30-32h内未崩解，这可能是由于PMMA的疏水性质所致。这些结果表明，接枝共聚物可能有助于克服胃的恶劣环境，并可用作结肠靶向基质的赋形剂。©2009 Wiley期刊，Inc.《应用理工学院》，2009
A series of acrylic monomers–starch graft copolymers were prepared by ceric ion initiation method by varying the amount of monomers. These graft copolymers were characterized by IR and 13C-NMR spectroscopy. It was seen that as the concentration of monomer [acrylic acid (AA), methacrylic acid (MA), and methyl methacrylate (MMA)] increased the percent add-on increased in all the graft copolymers, whereas grafting efficiency increased initially but showed a slight decrease with further increase in the monomer concentration (except for MMA). The release rate of paracetamol as a model drug from graft copolymers as well as their blends was studied at two different pH, 1.2 and 7.4, spectrophotometrically. The release of paracetamol in phosphate buffer solution at pH 1.2 was insignificant in the first 3 h for St-g-PAA- and St-g-PMA-graft copolymers, which was attributed to the matrix compaction and stabilization through hydrogen bonding at lower pH. At pH 7.4, the release rate was seen to decrease with increase in add-on. The tablet containing poly(methyl methacrylate) (PMMA) did not disintegrate at the end of 30–32 h, which may be attributed to the hydrophobic nature of PMMA. These results indicate that the graft copolymers may be useful to overcome the harsh environment of the stomach and can be used as excipients in colon-targeting matrices. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009