NEONATAL FRONTAL CORTICAL-LESIONS IN RATS ALTER CORTICAL STRUCTURE AND CONNECTIVITY
NEONATAL FRONTAL CORTICAL-LESIONS IN RATS ALTER CORTICAL STRUCTURE AND CONNECTIVITY
复制标题
DOI：
10.1016/0006-8993(94)91641-1
复制
发表时间：
1994-05-09
期刊：
影响因子：
2.9
通讯作者：
VANDERKOOY, D
中科院分区：
文献类型：
--
作者：
KOLB, B;GIBB, R;VANDERKOOY, D
大鼠在出生后第1天或第10天给予额叶皮质损伤。后来，作为成年人，他们要么：（1）用Golgi-Cox处理，以分析皮质树枝状结构;（2）向顶叶或视觉皮质注射True Blue，或者（3）向顶叶或视觉皮质注射[H-3]亮氨酸黑质。另一组正常大鼠在出生后第4天或第10天被注射荧光染料到大脑皮层。主要结果是：（1）成年大鼠损伤10天的大脑半球比正常大脑半球具有更大的树突乔木，（2）成年大鼠损伤1天的大脑半球相对于正常大脑半球具有更少的树突分支，（3）成年大鼠损伤10天的大脑半球皮层连接没有明显异常，（4）成年大鼠损伤1天的大脑半球具有异常的丘脑-皮层，杏仁-皮层，（5）4日龄正常大鼠脑内存在许多这种异常连接。由于在非常早期的额叶手术中的“异常”连接出现在第4天的动物中，因此它们似乎是由于病变后旺盛的连接未能缩回而导致的。第10天操作中增加的树突生长似乎与皮质传入或传出的定性变化无关，而可能与内在皮质连接性增加有关。由于先前已显示具有第10天损伤的大鼠表现出显著的功能恢复，因此可能增加的树突状分支支持功能恢复。
Rats were given frontal cortical lesions a day 1 or 10 of life. Later, as adults, they were either: (1) processed with Golgi-Cox in order to analyze cortical dendritic arborization; (2) given injections of True Blue into the parietal or visual cortex, or (3) given injections of [H-3]leucine into the substantia nigra. An additional group of normal rats were given injections of fluorescent dyes into the cortex on day 4 or 10 of life. The main findings were that (1) adult hemispheres with day 10 lesions had greater dendritic arbor than normal hemispheres, (2) adult hemispheres with day 1 lesions had reduced dendritic branching relative to normal hemispheres, (3) adult rats with day 10 lesions had no obvious abnormalities in cortical connections, (4) adult rats with day 1 lesions had abnormal thalamo-cortical, amygdalo-cortical, and nigro-cortical connections, and (5) many of these abnormal connections were present in the brains of 4-day-old normal rats. Since the 'abnormal' connections in the very early frontal operates were present in day 4 animals, it appears that they result from the failure of exuberant connections to retract after the lesions. The increased dendritic growth in day 10 operates does not appear related to qualitative changes in cortical afferents or efferents and may related to increased intrinsic cortical connectivity. Since rats with day 10 lesions have previously been shown to exhibit significant recovery of function, it is possible that the increased dendritic arborization is supporting the functional restitution.