Electron paramagnetic spectrum of dimanganic human serum transferrin.
Electron paramagnetic spectrum of dimanganic human serum transferrin.
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DOI：
10.1016/j.poly.2021.115224
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发表时间：
2021-04
期刊：
影响因子：
2.6
通讯作者：
Molly Lockart;K. Edwards;J. Vincent;B. Pierce
中科院分区：
文献类型：
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作者：
Molly Lockart;K. Edwards;J. Vincent;B. Pierce
锰（III）结合到金属转运蛋白转铁蛋白的EPR信号已被首次检测到。的EPR信号的温度依赖性和模拟是一致的Mn（III）的中心是六坐标在一个细长的四元环的环境。因此，在Tf活性位点内掺入Mn（III）不会极大地改变相对于天然Fe（III）2-Tf的配位数或活性位点几何形状。Mn（III）2-Tf的这种平行模式EPR信号可以证明对于旨在确定Mn（III）2-Tf的生理相关性的未来研究是有价值的。
An EPR signal for Mn(III) bound to the metal transport protein transferrin has been detected for the first time. The temperature dependence and simulations of the EPR signal are consistent with the Mn(III) centers being six-coordinate in an elongated tetragonal environment. Thus, the incorporation of Mn(III) within the Tf active site does not vastly alter the coordination number or active site geometry relative to native Fe(III)2-Tf. This parallel mode EPR signal for Mn(III)2-Tf could prove valuable for future studies aimed at determining the physiological relevance of Mn(III)2-Tf.