A pulmonary metastatic model of murine melanoma assessed by magnetic resonance imaging.
A pulmonary metastatic model of murine melanoma assessed by magnetic resonance imaging.
复制标题
通过磁共振成像评估小鼠黑色素瘤的肺转移模型。
作者：
Numata T;Kiryu S;Maeda T;Egusa C;Tsuboi R;Harada K
免疫检查点抑制剂和激酶抑制剂改善了恶性黑素瘤（MM）患者的预后。然而，这些疗法不能完全克服MM的转移。因此，应需要开发新的抗转移疗法。实现这一目标的第一步，本研究的目的，是建立一个模型的肺转移从原发性皮肤MM和监测系统。将B16-F10（一种鼠黑素瘤细胞系）皮下注射到小鼠耳廓中。当检测到病变时切除耳廓。耳廓切除后4周，在T2加权成像上检测到转移性结节。肺转移率为37.5%（6/16）。我们建立了一个新的小鼠模型的高度肺转移的MM。MRI是有用的观察生长的转移病灶在肺没有解剖。
Immune checkpoint inhibitors and kinase inhibitors have improved prognosis of malignant melanoma (MM) patients. However, these therapies cannot completely overcome the metastasis of MM. Thus, development of new therapy against metastasis should be required. A first step towards this goal, the aim of this study, is to establish a model of pulmonary metastasis from primary cutaneous MM and a monitoring system. B16‐F10, a murine melanoma cell line, was subcutaneously injected into the pinna of mice. The pinna was excised when the lesion was detected. A metastatic nodule on T2‐weighted imaging was detected 4 weeks after resection of the pinna. Lung metastases were observed in 37.5% (6/16) of the specimens. We established a novel murine model of the high pulmonary metastasis of MM. The MRI was useful for observations of the growth of the metastatic lesions in the lungs without dissection.