Antinociceptive efficacy of lacosamide in a rat model for painful diabetic neuropathy
Antinociceptive efficacy of lacosamide in a rat model for painful diabetic neuropathy
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DOI：
10.1016/j.ejphar.2006.04.009
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发表时间：
2006-06-06
影响因子：
5
通讯作者：
Stoehr, Thomas
中科院分区：
文献类型：
--
作者：
Beyreuther, Bettina;Callizot, Noelle;Stoehr, Thomas
在糖尿病神经性疼痛的链脲佐菌素大鼠模型上测试乳糖胺，并与治疗糖尿病神经性疼痛的常用药物，即抗抑郁药和抗惊厥药进行比较。在糖尿病大鼠中，乳糖胺减轻寒冷(10，30 mg/kg，i.p.)、温暖(3，10，30 mg/kg，i.p.)。机械性痛觉超敏(30 mg/kg，ip)。链脲佐菌素所致的热痛敏和机械性痛敏可被乳糖胺10 mg/kg和30 mg/kg，ip。吗啡(3 mg/kg)对痛觉过敏和痛觉过敏的疗效相似。阿米替林(10 mg/kg)、文拉法辛(15 mg/kg)、左乙拉西坦(180 mg/kg)和普瑞巴林(100 mg/kg)对热痛和机械性痛觉过敏均有明显的治疗作用。单用阿米替林(30 mg/kg，ip)。完全逆转了热过敏，堪比乳糖胺。拉莫三嗪(45 mg/kg，i.p.)对两种行为读数都没有影响。乳糖胺逆转疼痛行为的效力和疗效可能是由于其新的、尚不清楚的作用机制。(C)2006爱思唯尔B.V.保留所有权利。
Lacosamide was tested in the streptozotocin rat model of diabetic neuropathic pain in comparison to drugs which are commonly used in the treatment of diabetic neuropathic pain, i.e. antidepressants and anticonvulsants. In diabetic rats, lacosamide attenuated cold (10, 30 mg/kg, i.p.), warm (3, 10, 30 mg/kg, i.p.) and mechanical allodynia (30 mg/kg, i.p.). Streptozotocin-induced thermal and mechanical hyperalgesia were reduced by lacosamide at doses of 10 and 30 mg/kg, i.p. Morphine (3 mg/kg) showed similar efficacy on allodynia and hyperalgesia. Amitriptyline (10 mg/ kg), venlafaxine (15 mg/kg), levetiracetam (180 mg/kg) and pregabalin (100 mg/kg) exhibited significant effects on thermal allodynia and mechanical hyperalgesia. Only treatment with amitriptyline (30 mg/kg, i.p.) produced full reversal of thermal allodynia comparable to lacosamide. Lamotrigine (45 mg/kg, i.p.) had no effect on both behavioral readouts. Lacosamide's potency and efficacy in reversing pain behavior might be due to its new, yet unknown mechanism of action. (c) 2006 Elsevier B.V. All rights reserved.