Longitudinal Trajectories of Everyday Function by Diagnostic Status
Longitudinal Trajectories of Everyday Function by Diagnostic Status
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DOI：
10.1037/a0034069
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发表时间：
2013-12-01
影响因子：
3.7
通讯作者：
Beckett, Laurel
中科院分区：
文献类型：
--
作者：
Farias, Sarah Tomaszewski;Chou, Elizabeth;Beckett, Laurel
广义线性混合模型用于检查诊断稳定性/进展的日常功能限制的纵向轨迹。老年人（N = 384）平均随访3.6年;参与者按研究基线和末次随访时的诊断分组（每个时间点的正常认知、轻度认知障碍或痴呆）。在研究基线时，存在明显的组间差异;最明显的是，在最初被描述为认知正常的参与者中，与那些保持认知正常的人相比，那些在随访中发展为轻度认知障碍或痴呆的人已经表现出更大的功能障碍。在早期疾病组中，功能障碍的变化进展缓慢，但在转化为痴呆的患者中显示出加速恶化。
Generalized linear mixed models were used to examine longitudinal trajectories of everyday functional limitations by diagnostic stability/progression. Older adults (N = 384) were followed an average 3.6 years; participants were grouped by diagnosis at study baseline and last follow-up (normal cognition, Mild Cognitive Impairment, or dementia at each time point). At study baseline there were clear group differences; most notably among participants initially characterized as cognitively normal, those who developed Mild Cognitive Impairment or dementia over follow-up already demonstrated greater functional impairment compared with those who remained cognitively normal. Change in functional impairment progressed slowly in the early disease groups, but showed an accelerated worsening in those converting to dementia.