ACTH Secreting Transplantable Pituitary Tumors.∗ †
ACTH Secreting Transplantable Pituitary Tumors.∗ †
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分泌促肾上腺皮质激素的可移植性垂体肿瘤 † †
DOI：
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发表时间：
1953
期刊：
影响因子：
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通讯作者：
A. C. Upton
中科院分区：
文献类型：
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作者：
Jacob Furth;E. L. Gadsen;A. C. Upton
摘要和结论 暴露于电离辐射的小鼠中发生的两种垂体肿瘤被证明很容易移植，导致受体肥胖，伴有胸腺萎缩、高血糖、多尿，有时伴有糖尿、严重淋巴细胞减少和肾上腺皮质肥大。根据这些发现得出的结论是该肿瘤分泌ACTH。缺乏对肾上腺以外的任何内分泌器官的刺激的证据。
Summary and Conclusions Two pituitary tumors occurring in mice exposed to ionizing irradiation proved readily transplantable causing in the recipients obesity with thymic atrophy, hyperglycemia, polyuria, sometimes with glycosuria, severe lymphocytopenia, and hypertrophy of the adrenal cortex. On the basis of these findings it is concluded that this tumor secretes ACTH. There is lack of evidence of stimulation of any endocrine organ other than the adrenal.