Effects of AMP-activated protein kinase in cerebral ischemia.
Effects of AMP-activated protein kinase in cerebral ischemia.
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DOI：
10.1038/jcbfm.2009.255
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发表时间：
2010-03
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影响因子：
--
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中科院分区：
文献类型：
--
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AMP活化蛋白激酶（AMPK）是一种丝氨酸苏氨酸激酶，在进化过程中高度保守。AMPK存在于大多数哺乳动物组织中，包括大脑。AMPK作为一种重要的代谢和应激传感器/效应器，在营养缺乏、剧烈运动或热休克条件下被激活。然而，人们越来越认识到，AMPK激活的变化不仅是未满足的代谢需求的信号，而且还涉及对“细胞应激”（包括缺血）的感知和响应。AMPK激活的下游效应取决于许多因素，包括应激源的严重程度以及检查的组织。这篇综述讨论了最近在脑/神经元细胞和血管系统中进行的体外和体内研究，这些研究有助于我们了解AMPK在中风中的作用。AMPK在血管生成和神经发生中的潜在作用以及AMPK与3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂（他汀类药物）的相互作用的最新数据突出显示。AMPK和一氧化氮信号之间的相互作用进行了讨论。
AMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK is found in most mammalian tissues including the brain. As a key metabolic and stress sensor/effector, AMPK is activated under conditions of nutrient deprivation, vigorous exercise, or heat shock. However, it is becoming increasingly recognized that changes in AMPK activation not only signal unmet metabolic needs, but also are involved in sensing and responding to ‘cell stress’, including ischemia. The downstream effect of AMPK activation is dependent on many factors, including the severity of the stressor as well as the tissue examined. This review discusses recent in vitro and in vivo studies performed in the brain/neuronal cells and vasculature that have contributed to our understanding of AMPK in stroke. Recent data on the potential role of AMPK in angiogenesis and neurogenesis and the interaction of AMPK with 3-hydroxy-3-methy-glutaryl-CoA reductase inhibitors (statins) agents are highlighted. The interaction between AMPK and nitric oxide signaling is also discussed.
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影响因子：
11.8
作者：
Dasgupta, Biplab;Milbrandt, Jeffrey
通讯作者：
Milbrandt, Jeffrey
影响因子：
4.8
作者：
Choi, Hyoung Chul;Song, Ping;Zou, Ming-Hui
通讯作者：
Zou, Ming-Hui
影响因子：
8.3
作者：
Alvarez-Sabín, J;Molina, CA;Quintana, M
通讯作者：
Quintana, M
DOI：
10.1016/0167-4889(94)00222-z
发表时间：
1995-04-06
影响因子：
5.1
作者：
GAO, G;WIDMER, J;WITTERS, LA
通讯作者：
WITTERS, LA
影响因子：
9.9
作者：
Chaturvedi, S.;Zivin, J.;Welch, M. A.
通讯作者：
Welch, M. A.