Enhancing Hispanic participation in mental health clinical research: development of a Spanish-speaking depression research site.
Enhancing Hispanic participation in mental health clinical research: development of a Spanish-speaking depression research site.
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DOI：
10.1002/da.22153
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发表时间：
2014-03
影响因子：
7.4
通讯作者：
Craighead, W. Edward
中科院分区：
文献类型：
--
作者：
Aponte-Rivera, Vivianne;Dunlop, Boadie W.;Ramirez, Cynthia;Kelley, Mary E.;Schneider, Rebecca;Blastos, Beatriz;Larson, Jacqueline;Mercado, Flavia;Mayberg, Helen;Craighead, W. Edward
西班牙裔，特别是那些英语水平有限的人，在精神病临床研究中的代表性不足。我们开发了一个双语和双文化的研究诊所，致力于招募和治疗西班牙语受试者的抑郁症缓解预测因子个体和联合治疗（PReDICT）研究，这是一项针对未接受过治疗的重度抑郁症（MDD）受试者的大型临床试验。在西班牙语研究中心（N=275）和主要英语研究中心（N=899）之间比较了来自前1，174例参加研究的受试者筛选评价的人口统计学和临床数据。统计了每家临床试验机构PReDICT研究的不合格原因（N=888）。与讲英语的人相比，讲西班牙语的人受教育程度较低，更有可能是女性，没有保险，并且有不受控制的医疗条件。在临床上，西班牙语演讲者表现出更大的抑郁症的严重程度，更高的平均症状严重程度评分，和更多的以前的自杀企图。在未被随机分配到PReDICT研究的受试者中，讲西班牙语的受试者更有可能患有不受控制的医疗状况或拒绝参与，而讲英语的受试者更有可能患有双相情感障碍或非MDD抑郁障碍。招募患有MDD的西班牙裔受试者是可行的，并且可能会加强信号检测的努力，因为在临床试验中讲西班牙语的参与者中抑郁症的严重程度更高。需要采取具体办法征聘和留住讲西班牙语的与会者。
Hispanics, particularly those with limited English proficiency, are underrepresented in psychiatric clinical research studies. We developed a bilingual and bicultural research clinic dedicated to the recruitment and treatment of Spanish-speaking subjects in the Predictors of Remission in Depression to Individual and Combined Treatments (PReDICT) study, a large clinical trial of treatment-naïve subjects with major depressive disorder (MDD). Demographic and clinical data derived from screening evaluations of the first 1,174 subjects presenting for participation were compared between the Spanish-speaking site (N=275) and the primary English-speaking site (N=899). Reasons for ineligibility (N=888) for the PReDICT study were tallied for each site. Compared to English-speakers, Spanish-speakers had a lower level of education and were more likely to be female, uninsured, and have uncontrolled medical conditions. Clinically, Spanish-speakers demonstrated greater depression severity, with higher mean symptom severity scores, and a greater number of previous suicide attempts. Among the subjects who were not randomized into the PReDICT study, Spanish-speaking subjects were more likely to have an uncontrolled medical condition or refuse participation, whereas English-speaking subjects were more likely to have bipolar disorder or a non-MDD depressive disorder. Recruitment of Hispanic subjects with MDD is feasible and may enhance efforts at signal detection, given the higher severity of depression among Spanish-speaking participants presenting for clinical trials. Specific approaches for the recruitment and retention of Spanish-speaking participants are required.
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DOI：
10.1097/00004583-199703000-00012
发表时间：
1997-03-01
影响因子：
13.3
作者：
Bernstein, DP;Ahluvalia, T;Handelsman, L
通讯作者：
Handelsman, L
影响因子：
2.7
作者：
Alvidrez, J
通讯作者：
Alvidrez, J
影响因子：
3.8
作者：
Alegria, Margarita;Chatterji, Pinka;Meng, Xiao-Li
通讯作者：
Meng, Xiao-Li
影响因子：
4.6
作者：
LIZARDI, H;KLEIN, DN;DONALDSON, SK
通讯作者：
DONALDSON, SK
影响因子：
7
作者：
Givens, Jane L.;Houston, Thomas K.;Cooper, Lisa A.
通讯作者：
Cooper, Lisa A.