Non-Invasive ESR Measurements for in vivo Kinetic Studies of a Nitroxide Radical in the Liver of a Rat by a Surface-Coil-Type Resonator under a Field Gradient
Non-Invasive ESR Measurements for in vivo Kinetic Studies of a Nitroxide Radical in the Liver of a Rat by a Surface-Coil-Type Resonator under a Field Gradient
复制标题
通过表面线圈型谐振器在场梯度下对大鼠肝脏中氮氧自由基的体内动力学研究进行无创 ESR 测量
DOI：
10.1246/cl.2000.1000
复制
发表时间：
2000
影响因子：
1.6
通讯作者：
H. Kamada
中科院分区：
文献类型：
--
作者：
H. Yokoyama;M. Tada;Toshiyuki Sato;H. Ohya;H. Kamada
A non-invasive ESR measuring method for in vivo kinetic studies of a nitroxide radical in the liver of a rat by combining a surface-coil-type resonator (SCR) and field gradient method was developed. The depth across which a microwave magnetic field (B1) can penetrate under the SCR was about 4 mm. Using the SCR, ESR measurements without any invasive surgical procedures were made on the upper abdomen of a rat that received an intravenous injection of a nitroxide radical under a field gradient along the B1-direction. It was found that the decay rate of nitroxide radical 4 mm under the skin (i.e., in the liver) is fast compared to that near the skin.
