A study of the association between Crohn's disease and psychiatric illness.
A study of the association between Crohn's disease and psychiatric illness.
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DOI：
10.5555/uri:pii:0016508584904189
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发表时间：
1984
期刊：
影响因子：
29.4
通讯作者：
J. Helzer;S. Chammas;C. Norland;W. A. Stillings;D. Alpers
中科院分区：
文献类型：
--
作者：
J. Helzer;S. Chammas;C. Norland;W. A. Stillings;D. Alpers
这项研究是通过仔细的胃肠道评估、已知的信度和效度的结构化精神病学访谈和明确的精神疾病诊断标准来检验克罗恩病和精神疾病之间的联系。来自一所大学诊所和一家私人诊所的50名克罗恩病患者的先证者样本。来自相同的两个临床来源的50名慢性内科疾病的对照受试者也被检查。与对照组相比，克罗恩病患者在一生中的某个时候符合某些精神障碍的标准的人数明显更多，被诊断为抑郁症的人数也明显更多。有更多的先证者报告强迫或恐怖症状，且先证者的强迫症状平均数高于对照组。我们没有发现精神障碍和克罗恩病之间存在相互作用的证据。讨论了发现的联系对克罗恩病的治疗和自然病史的意义。
This study is an examination of the association between Crohn's disease and psychiatric illness using careful gastrointestinal evaluation, a structured psychiatric interview of known reliability and validity, and explicit diagnostic criteria for psychiatric illness. A proband sample of 50 subjects with Crohn's disease was obtained from a university clinic and a private clinic. Fifty control subjects with chronic medical illnesses obtained from the same two clinic sources were also examined. Compared with controls, a significantly greater number of the patients with Crohn's disease met criteria for some psychiatric disorder at some time in their lives, and a significantly greater number had a diagnosis of depression. A greater number of the probands reported obsessional or phobic symptoms, and the mean number of obsessional symptoms was higher in probands than in controls. We found no evidence of an interaction between psychiatric disorder and Crohn's disease. The significance of the discovered association for the treatment and natural history of Crohn's disease is discussed.