Evaluation of variation of saliva iodine and recommendations for sample size and sampling time: Implications for assessing iodine nutritional status
Evaluation of variation of saliva iodine and recommendations for sample size and sampling time: Implications for assessing iodine nutritional status
复制标题
唾液碘变化的评估以及样本量和采样时间的建议：对评估碘营养状况的影响。
DOI：
10.1016/j.clnu.2020.12.010
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发表时间：
2021-05-01
影响因子：
6.3
通讯作者：
Zhang, Wanqi
中科院分区：
文献类型：
--
作者：
Guo, Wenxing;Dong, Shuyao;Zhang, Wanqi
背景：唾液碘浓度（SIC）已被发现是碘营养状况的良好指标。然而，有限的信息是关于唾液碘characteristics.Aims：本研究旨在评估日内，个体内，和人口SIC的变化，以提供信息的最佳样本量和采样时间评估碘营养state.Methods：29名健康学龄学生被招募。在三天的时间内，对从饮食和水中摄入的碘以及通过尿液和粪便排泄的碘进行了评估。结果：碘摄入量与唾液中SIC的日变化相对应。SIC的平均CV不仅在个体水平（42.73% vs. 47.71%和49.69%），而且在群体水平（71.29% vs. 100.43%和72.49%）均低于24小时尿碘浓度（24小时UIC）和24小时尿碘排泄量（24小时UIE）。估计碘水平所需的唾液样本数量（95% CI在+/-10%，+/- 20%的精确度范围内）为55.14（个体）和180.45（人群）。结论：唾液碘可用于评价个体和人群近期碘营养状况。SIC的变化低于24小时UIC和24小时UIE。唾液比尿液更容易收集，因此更受欢迎。需要14个样本来评估个体碘状态，需要45个唾液样本来评估人群碘状态，并具有合理的精度。我们建议在一天中的14：00之后收集唾液样本。(c)2020由Elsevier Ltd.出版
Background: Saliva iodine concentration (SIC) has been found to be a good indicator of iodine nutritional status. However, limited information is available regarding saliva iodine characteristics.Aims: The study aimed to evaluate intra-day, intra-individual, and population SIC variation in order to provide information on optimal sample size and sampling time for assessing iodine nutritional status.Methods: Twenty-nine healthy school-aged students were recruited. Iodine intake from diet and water, and iodine excretion through urine and feces were assessed over a three-day period. Saliva samples were collected six times a day.Results: Diurnal variations were observed in SIC corresponding to iodine intake. The mean CV in SIC was lower than that for 24-hour urinary iodine concentration (24-h UIC) and 24-hour urinary iodine excretion (24-h UIE) not only at the individual level (42.73% vs. 47.71% and 49.69%) but also at the population level (71.29% vs. 100.43% and 72.49%). The number of saliva samples needed to estimate the iodine level with 95% CI within precision ranges of +/- 10%, +/- 20% was 55,14 in an individual, and 180, 45 in a population. There was a good correlation between post-lunch SIC and total daily iodine intake.Conclusions: Saliva iodine has utility for evaluating the recent iodine nutrition of individuals and populations. The variation in SIC was lower than that for 24-h UIC and 24-h UIE. Saliva may be preferred over urine because of its ease of collection. Fourteen samples are needed to assess individual iodine status and forty-five saliva samples for assessment of population iodine status with reasonable precision. We recommend that saliva samples be collected after 14:00 in a day. (c) 2020 Published by Elsevier Ltd.