Targeting the central nervous system inflammatory response in ischemic stroke
Targeting the central nervous system inflammatory response in ischemic stroke
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DOI：
10.1097/00019052-200106000-00014
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发表时间：
2001-06-01
影响因子：
4.8
通讯作者：
Becker, KJ
中科院分区：
文献类型：
--
作者：
Becker, KJ
在中风的实验模型中，炎症似乎与脑缺血损伤有关。然而，到目前为止，旨在限制缺血后炎症反应的临床试验结果令人失望。这些临床失败可能反映了这样一个事实，即没有足够的临床前数据和不充分的试验设计，而不是提供证据反对炎症在缺血性脑损伤中的作用。Curr Opin Neurol 14：349-353。(C)2001年，Lippincott Williams&Wilkins。
In experimental models of stroke, inflammation appears to contribute to cerebral ischemic injury. Clinical trials that are aimed at limiting the postischemic inflammatory response, however, have thus far had disappointing results. These clinical failures probably reflect the fact that there has been insufficient preclinical data and inadequate trial design, rather than provide evidence against a role for inflammation in ischemic brain injury. Curr Opin Neurol 14:349-353. (C) 2001 Lippincott Williams & Wilkins.