Characterization of the UVA Protection Provided by Avobenzone, Zinc Oxide, and Titanium Dioxide in Broad-Spectrum Sunscreen Products
Characterization of the UVA Protection Provided by Avobenzone, Zinc Oxide, and Titanium Dioxide in Broad-Spectrum Sunscreen Products
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DOI：
10.2165/11537050-000000000-00000
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发表时间：
2010-01-01
影响因子：
7.3
通讯作者：
Meyer, Thomas A.
中科院分区：
文献类型：
--
作者：
Beasley, Donathan G.;Meyer, Thomas A.
Background: Solar UV radiation (UVR) is composed of UVB (290-320 nm) and UVA (320-400 nm) wavelengths. Only two sunscreen active ingredients approved in the US, avobenzone (butylmethoxy-dibenzoylmethane) and zinc oxide (ZnO), provide true broad-spectrum protection against UVA wavelengths >360 nm. Although effective against shorter UVR wavelengths 360 nm compared with formulas containing 5% TiO2. Additionally, sunscreen products of similar SPF containing avobenzone or ZnO exhibited significantly higher PFA values than those containing TiO2. The addition of photostabilized avobenzone or ZnO increased PFA values nearly 3-fold, whereas the addition of TiO2 increased P FA values only modestly. Judicious selection of sunscreen actives alone or in combination with extra stabilizing agents maintained the photostability of avobenzone in formulations to deliver sustained broad-spectrum absorbance during 4 hours of exposure to UVR. Small losses (
