Intestinal neurotransmitters and PARS activation in streptozotocin induced diabetic rats
Intestinal neurotransmitters and PARS activation in streptozotocin induced diabetic rats
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链脲佐菌素诱导的糖尿病大鼠肠道神经递质和 PARS 激活
DOI：
10.1055/s-2004-827107
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
E. Fehér
中科院分区：
文献类型：
--
作者：
K. Altdorfer;B. Batbayar;E. Fehér
结果如下：VIP免疫阳性神经主要分布于平滑肌层和壁内神经丛，NPY和TH免疫阳性神经主要分布于对照组大鼠动脉周围网络。定量分析显示，糖尿病大鼠小肠SP、VIP和SOM IR神经纤维密度增加。在免疫活性细胞附近观察到这些免疫标记的神经。结论：糖尿病患者神经递质平衡的改变和PARS的激活可引起多种炎症反应，可能是糖尿病肠病肠道炎症和动力障碍的发病机制之一。
Results: VIP IR nerves were found mostly in the smooth muscle layers and in the intramural nerve plexuses; NPY and TH IR nerves were seen mostly in the periarterial networks of control rats. In the diabetic intestine the quantitative analysis revealed that the density of SP, VIP and SOM IR nerve fibres was increased. These immunolabelled nerves were observed in close vicinity of immunocompetent cells. Pars Ir connective tissue cells appeared in significantly higher number in the diabetic (inflamed) specimens.Conclusion: The alteration of the neurotransmitter balance and PARS activation seen in diabetes can cause various inflammatory responses and might be one of the key factors in the pathogenesis of intestinal inflammation and motility disorders of diabetic enteropathy.