Ca permeable AMPA channels in diseases of the nervous system.
Ca permeable AMPA channels in diseases of the nervous system.
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DOI：
10.3389/fnmol.2011.00042
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发表时间：
2011
影响因子：
4.8
通讯作者：
Weiss JH
中科院分区：
文献类型：
--
作者：
Weiss JH
自从二十多年前发现 Ca2+ 通透性 AMPA 通道并进行分子表征以来，已经积累了大量证据，表明这些不寻常的谷氨酸激活通道在某些条件下（包括缺血和肌萎缩侧索硬化症）选择性神经变性的贡献。它们对疾病的贡献可能涉及的因素包括它们在某些神经元群体中的独特表达模式、它们通过各种机制响应疾病相关应激而上调，以及它们对 Zn2+ 和 Ca2+ 的高渗透性。然而，由于缺乏可用于动物或人类的这些通道的选择性和生物可利用的阻断剂，对它们对某些疾病的贡献以及治疗方法的开发的全面表征受到限制。这篇综述总结了近年来出现的一些关于这些通道在疾病中的贡献的线索。
Since the discovery and molecular characterization of Ca2+-permeable AMPA channels just over two decades ago, a large body of evidence has accumulated implicating contributions of these unusual glutamate activated channels to selective neurodegeneration in certain conditions, including ischemia and amyotrophic lateral sclerosis. Factors likely involved in their contributions to disease include their distinct patterns of expression in certain neuronal populations, their upregulation via various mechanisms in response to disease associated stresses, and their high permeability to Zn2+ as well as to Ca2+. However, full characterization of their contributions to certain diseases as well as development of therapeutics has been limited by the lack of selective and bioavailable blockers of these channels that can be employed in animals or humans. This review summarizes some of the clues that have emerged over recent years to the contributions of these channels in disease.
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影响因子：
5.3
作者：
Grossman, SD;Wolfe, BB;Wrathall, JR
通讯作者：
Wrathall, JR
DOI：
10.1074/jbc.m901203200
发表时间：
2009-05-22
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Dixon RM;Mellor JR;Hanley JG
通讯作者：
Hanley JG
影响因子：
5.3
作者：
Bonanni, Laura;Chachar, Mushtaque;Jonas, Elizabeth A.
通讯作者：
Jonas, Elizabeth A.
影响因子：
5.3
作者：
Calderone, A;Jover, T;Zukin, RS
通讯作者：
Zukin, RS
影响因子：
11.2
作者：
ALEXIANU, ME;HO, BK;APPEL, SH
通讯作者：
APPEL, SH