SNPs in Dopamine D2 Receptor Gene (DRD2) and Norepinephrine Transporter Gene (NET) are Associated With Continuous Performance Task (CPT) Phenotypes in ADHD Children and Their Families
SNPs in Dopamine D2 Receptor Gene (DRD2) and Norepinephrine Transporter Gene (NET) are Associated With Continuous Performance Task (CPT) Phenotypes in ADHD Children and Their Families
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DOI：
10.1002/ajmg.b.30876
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发表时间：
2008-12-05
影响因子：
2.8
通讯作者：
Ashley-Koch, A. E.
中科院分区：
文献类型：
--
作者：
Kollins, S. H.;Anastopoulos, A. D.;Ashley-Koch, A. E.
进行单倍型标记 SNP 分析，以确定源自连续表现任务 (CPT) 表现的定量表型的分子遗传底物。从 152 个家庭中抽取了 364 名个体，根据至少一名儿童患有 ADHD 的情况确定。先证者、他们受影响和未受影响的兄弟姐妹以及父母均接受了 CPT。分析和测试了性能的四个不同组成部分与涉及单胺能功能的 10 个候选基因的 SNP 的关联。在校正多重比较并控制来自同一家庭的多个个体后，发现委托错误与 DRD2 基因中的 SNP（rs2075654、rs1079596）之间以及反应时间变异性与 NET 基因中的 SNP（rs3785155）之间存在显着关联。这些发现表明，根据之前发布的标准，委托错误和反应时间变异是 ADHD 内表型的绝佳候选者。结果还揭示了可能构成该疾病的特定过程的分子遗传基础。 (C) 2008 Wiley-Liss, Inc.
Haplotype-tagging SNP analyses were conducted to identify molecular genetic substrates of quantitative phenotypes derived from performance on a Continuous Performance Task (CPT). Three hundred sixty-four individuals were sampled from 152 families ascertained on the basis of at least one child having ADHD. Probands, their affected and unaffected siblings, and parents were administered a CPT. Four different components of performance were analyzed and tested for association with SNPs from 10 candidate genes involved in monoaminergic function. After correcting for multiple comparisons and controlling for multiple individuals from the same family, significant associations were identified between commission errors and SNPs in the DRD2 gene (rs2075654, rs1079596), and between reaction time variability and a SNP in the NET gene (rs3785155). These findings suggest that commission errors and reaction time variability are excellent candidates as ADHD endophenotypes based on previously published criteria. Results also shed light on the molecular genetic basis of specific processes that may underlie the disorder. (C) 2008 Wiley-Liss, Inc.