Cholinergic effects on gallbladder emptying in humans.
Cholinergic effects on gallbladder emptying in humans.
复制标题
胆碱能对人类胆囊排空的影响。
DOI：
10.1016/0016-5085(85)90564-5
复制
发表时间：
1985
期刊：
影响因子：
29.4
通讯作者：
Malmud,LS
中科院分区：
文献类型：
--
作者：
Fisher,RS;Rock,E;Malmud,LS
胆碱能机制在控制胆囊排空中的作用尚未明确。本文用~(99)m标记的2，6-二甲基苯氨基甲基亚氨基二乙酸和~(111)In标记的二乙三胺五乙酸显显胃及其排空，对43例正常人和18例迷走神经切断术患者进行了研究。直接胆碱能刺激可引起显著的胆囊排空。用硫酸阿托品阻断胆碱能降低了对液体餐、固体餐和注射八肽缩胆囊素的胆碱能排空反应。在迷走神经切断术的患者中，尽管摄入的液体餐加速了胃排空，但胆囊排空却减少了。在接受迷走神经切断术的患者中，八肽缩胆囊素的胆囊排空反应增强。这些研究表明，胆碱能受体可能在人体胆囊排空的调节中起重要作用。
The role of cholinergic mechanisms in the control of gallbladder emptying has not been defined. In this report a scintigraphic technique using 2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid labeled with technetium 99m to visualize the gallbladder and its emptying and diethylenetriamine pentaacetic acid labeled with indium 111 to visualize the stomach and its emptying was used to study 43 normal subjects and 18 patients with vagotomies. Direct cholinergic stimulation with bethanechol induced significant gallbladder emptying. Cholinergic blockade with atropine sulfate decreased the gallbladder emptying responses to a liquid meal, a solid meal, and the infusion of cholecystokinin-octapeptide. In patients with vagotomies, gallbladder emptying was decreased despite accelerated gastric emptying of an ingested liquid meal. The gallbladder emptying response to cholecystokinin-octapeptide was augmented in patients who had undergone vagotomy. These studies suggest that cholinergic receptors may be important in the regulation of human gallbladder emptying.