Relationship between haemagglutination-inhibiting antibody titres and clinical protection against influenza: development and application of a bayesian random-effects model.
Relationship between haemagglutination-inhibiting antibody titres and clinical protection against influenza: development and application of a bayesian random-effects model.
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DOI：
10.1186/1471-2288-10-18
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发表时间：
2010-03-08
影响因子：
4
通讯作者：
Ecochard R
中科院分区：
文献类型：
--
作者：
Coudeville L;Bailleux F;Riche B;Megas F;Andre P;Ecochard R
针对血凝素的抗体，通过血凝抑制（HI）试验测量，对流感感染的保护性免疫至关重要。一般认为，甲流滴度为1:40表示易感人群感染流感的风险降低50%，但进一步量化甲流滴度与保护效果之间关系的尝试有限。我们提出了一个模型，使用荟萃分析方法，估计在任何流感滴度水平的临床保护水平。源数据来自一项系统文献综述，该文献综述确定了15项研究，共涉及5899名成人受试者和1304例流感病例，其中有间隔审查的HI滴度信息。在考虑随机效应和现有信息审查的情况下，使用贝叶斯推理估计HI滴度与临床保护之间关系的参数。在所有测试的模型中，都观察到流感滴度与临床预防流感之间存在显著的正相关关系。无论病毒株类型（A或B）和个体的疫苗接种状况如何，这种关系都是相似的。虽然所使用数据的局限性不应被忽视，但在只有免疫原性数据的情况下，本分析得出的关系为预测灭活流感疫苗的效力提供了一种手段。这种关系也可用于根据不同流感疫苗的免疫特性来比较它们的效力。
Antibodies directed against haemagglutinin, measured by the haemagglutination inhibition (HI) assay are essential to protective immunity against influenza infection. An HI titre of 1:40 is generally accepted to correspond to a 50% reduction in the risk of contracting influenza in a susceptible population, but limited attempts have been made to further quantify the association between HI titre and protective efficacy. We present a model, using a meta-analytical approach, that estimates the level of clinical protection against influenza at any HI titre level. Source data were derived from a systematic literature review that identified 15 studies, representing a total of 5899 adult subjects and 1304 influenza cases with interval-censored information on HI titre. The parameters of the relationship between HI titre and clinical protection were estimated using Bayesian inference with a consideration of random effects and censorship in the available information. A significant and positive relationship between HI titre and clinical protection against influenza was observed in all tested models. This relationship was found to be similar irrespective of the type of viral strain (A or B) and the vaccination status of the individuals. Although limitations in the data used should not be overlooked, the relationship derived in this analysis provides a means to predict the efficacy of inactivated influenza vaccines when only immunogenicity data are available. This relationship can also be useful for comparing the efficacy of different influenza vaccines based on their immunological profile.
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影响因子：
5
作者：
Hannoun, C;Megas, F;Piercy, J
通讯作者：
Piercy, J
DOI：
10.1001/jama.1957.02980290006002
发表时间：
1957-01-01
影响因子：
120.7
作者：
BELL, JA;WARD, TG;HUEBNER, RJ
通讯作者：
HUEBNER, RJ
影响因子：
5.5
作者：
Kohberger, Robert C.;Jemiolo, David;Noriega, Fernando
通讯作者：
Noriega, Fernando
影响因子：
2.4
作者：
Brooks, SP;Gelman, A
通讯作者：
Gelman, A
影响因子：
5
作者：
FOX, JP;COONEY, MK;FOY, HM
通讯作者：
FOY, HM