Age-dependent impairment of angiogenesis
Age-dependent impairment of angiogenesis
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DOI：
10.1161/01.cir.99.1.111
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发表时间：
1999-01-12
期刊：
影响因子：
37.8
通讯作者：
Isner, JM
中科院分区：
文献类型：
--
作者：
Rivard, A;Fabre, JE;Isner, JM
背景--在缺血性血管疾病中，衰老对血管生成的影响尚未被研究。方法和结果：在切除1条股动脉40天后，老年(4-5岁；n=7)和年轻(6-8个月；n=6)新西兰白(NZW)兔的侧支血管发育明显受损，其基础是后肢血流灌注减少(缺血：正常血压比=0.58+/-0.05比0.77+/-0.06；P
Background-The effect of aging on angiogenesis in ischemic vascular disease has not been studied. Accordingly, we investigated the hypothesis that angiogenesis is impaired as a function of age.Methods and Results-Forty days after the resection of 1 femoral artery, collateral vessel development was significantly impaired in old (aged 4 to 5 years; n=7) versus young (aged 6 to 8 months; n=6) New Zealand White (NZW) rabbits on the basis of reduced hindlimb perfusion (ischemic: normal blood pressure ratio=0.58+/-0.05 versus 0.77+/-0.06; P