EVIDENCE THAT GAMMA-GLUTAMYL CYCLE FUNCTIONS INVIVO USING INTRACELLULAR GLUTATHIONE - EFFECTS OF AMINO-ACIDS AND SELECTIVE-INHIBITION OF ENZYMES
EVIDENCE THAT GAMMA-GLUTAMYL CYCLE FUNCTIONS INVIVO USING INTRACELLULAR GLUTATHIONE - EFFECTS OF AMINO-ACIDS AND SELECTIVE-INHIBITION OF ENZYMES
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DOI：
10.1073/pnas.75.11.5405
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发表时间：
1978-01-01
影响因子：
11.1
通讯作者：
MEISTER, A
中科院分区：
文献类型：
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作者：
GRIFFITH, OW;BRIDGES, RJ;MEISTER, A
在体内研究中探索了γ-谷氨酰循环的功能，其中将氨基酸和循环酶的特异性抑制剂(γ-谷氨酰转肽酶、γ-谷氨酰环转移酶、γ-谷氨酰半胱氨酸合成酶和5-氧代脯氨酸酶)给予小鼠。表明γ-谷氨酰循环在体内起作用的结果支持这样的结论：由γ-谷氨酰转肽酶从外部供应的氨基酸和细胞内谷胱甘肽形成的γ-谷氨酰氨基酸被易位到细胞中，因此表明谷胱甘肽的代谢和氨基酸的转运之间存在显着的生理联系。
The function of the .gamma.-glutamyl cycle was explored in vivo studies in which amino acids and specific inhibitors of cycle enzymes (.gamma.-glutamyl transpeptidase, .gamma.-glutamyl cyclotransferase, .gamma.-glutamylcysteine synthetase and 5-oxoprolinase) were administered to mice. The findings, which show that the .gamma.-glutamyl cycle functions in vivo, support the conclusion that .gamma.-glutamyl amino acids formed by .gamma.-glutamyl transpeptidase from externally supplied amino acids and intracellular glutathione are translocated into the cell and thus indicate that there is a significant physiological connection between the metabolism of glutathione and the transport of amino acids.