Adrenal function in abstinent alcoholic men.
Adrenal function in abstinent alcoholic men.
复制标题
戒酒男性的肾上腺功能。
DOI：
10.1016/0278-5846(91)90006-m
复制
发表时间：
1991
影响因子：
5.6
通讯作者：
Orth,DN
中科院分区：
文献类型：
--
作者：
Loosen,PT;Chambliss,B;Pavlou,SS;Orth,DN
1. The nocturnal secretion of plasma ACTH and serum cortisol and their responses to ovine corticotropin-releasing hormone (oCRH) were studied in acutely abstinent alcoholic and normal men. 2. Nocturnal cortisol secretion was similar in alcoholic and normal men, but nocturnal ACTH secretion tended to be decreased during the early morning hours (0600h-0900h) in alcoholic men. ACTH, but not cortisol, responses after oCRH administration tended to be attenuated in alcoholic men. CLUSTER ANALYSIS showed that the changes were not due to alterations in ACTH pulse frequency, amplitude, or interpulse interval. 3. The data suggest an intrinsic defect in response to CRH by the pituitary corticotroph cell, possibly due to genetic vulnerability or to the toxic effects of prolonged alcohol abuse.
