Protective effects of a chalcone derivative against Aβ-induced oxidative stress and neuronal damage
Protective effects of a chalcone derivative against Aβ-induced oxidative stress and neuronal damage
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DOI：
10.5483/bmbrep.2011.44.11.730
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发表时间：
2011-11-30
期刊：
影响因子：
3.8
通讯作者：
Yoon, Ho-Geun
中科院分区：
文献类型：
--
作者：
Kim, Mi-Jeong;Lee, Yoo-Hyun;Yoon, Ho-Geun
淀粉样β-肽(A-β-肽)诱导的氧化应激被认为是阿尔茨海默病(AD)病理生理学的重要组成部分。新的查尔酮衍生物Chana系列是最近从甘草的后查尔酮中合成的。在这项研究中，我们研究了CHANA系列在体外和体内对神经退行性变化的保护作用。在CHANA系列化合物中，CHANA 30对1，1-二苯基-2-苦基肼的清除活性最高(90.7%)。Chana 30在体外对Aβ诱导的神经细胞损伤也有保护作用。此外，Chana 30还减少了注射4β(1-42)多肽的小鼠的学习和记忆缺陷。综上所述，这些结果表明，Chana 30可能是一种很有前途的候选药物，可以作为治疗神经退行性疾病的有效药物。[BMB报告2011；44(11)：730-734]
Amyloid beta-peptide (A beta-peptide)-induced oxidative stress is thought to be a critical component of the pathophysiology of Alzheimer's disease (AD). New chalcone derivatives, the Chana series, were recently synthesized from the retrochalcones of licorice. In this study, we investigated the protective effects of the Chana series against neurodegenerative changes in vitro and in vivo. Among the Chana series, Chana 30 showed the highest free radical scavenging activity (90.7%) in the 1,1-diphenyl-2- picrylhydrazyl assay. Chana 30 also protected against A beta-induced neural cell injury in vitro. Furthermore, Chana 30 reduced the learning and memory deficits of 4 beta(1-42)-peptide injected mice. Taken together, these results suggest that Chana 30 may be a promising candidate as a potent therapeutic agent against neurodegenerative diseases. [BMB reports 2011; 44(11): 730-734]