Vascular progenitor cell mobilization.
Vascular progenitor cell mobilization.
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DOI：
10.1007/978-1-61779-943-3_13
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发表时间：
2012-01-01
期刊：
影响因子：
--
通讯作者：
Hirschi, Karen K
中科院分区：
文献类型：
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作者：
Kienstra, Kirsten A;Hirschi, Karen K
血管形成在生理和病理组织生长和愈合中起关键作用。因此，对新生血管形成机制的透彻理解将转化为各种疾病过程的创新临床治疗策略。血管前体/祖细胞群已从几种不同的组织类型中分离出来，并具有丰富的潜力用于血管再生策略。此外，循环内皮祖细胞（EPC）的水平已被证明与心血管和血管疾病的结果相关。EPC治疗已被证明可以改善心脏和外周血管缺血后的功能结局。最近的研究也证明了EPC在儿科疾病过程中的作用，如早产儿视网膜病变和支气管肺发育不良。此外，许多用于治疗血管疾病的药物影响EPC动员和功能。重要的是，血管损伤的类型似乎决定了新血管形成的机制，强调了仔细选择血管再生策略的重要性。
Blood vessel formation plays a key role in both physiologic and pathologic tissue growth and healing. Thus, a thorough understanding of the mechanisms underlying neovascularization will translate into innovative clinical treatment strategies for a wide variety of disease processes. Vascular precursor/progenitor cell populations have been isolated from several different tissue types and have a rich potential for use in vascular regenerative strategies. Furthermore, levels of circulating endothelial progenitor cells (EPC) have been shown to correlate with outcomes in cardiovascular and vascular diseases. Treatment with EPC has been shown to improve functional outcomes following cardiac and peripheral vascular ischemia. Recent studies have also demonstrated a role for EPC in pediatric disease processes such as retinopathy of prematurity and bronchopulmonary dysplasia. In addition, many of the drugs utilized to treat vascular disease impact EPC mobilization and function. Importantly, the type of vascular injury appears to dictate the mechanism of neovascularization, highlighting the importance of carefully selected vascular regenerative strategies.