Airways responsiveness in a population sample of adults and children.
Airways responsiveness in a population sample of adults and children.
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成人和儿童人群样本中的气道反应性。
DOI：
10.1164/arrd.1984.129.6.898
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Ingram,RH
中科院分区：
文献类型：
--
作者：
Weiss,ST;Tager,IB;Weiss,JW;Munoz,A;Speizer,FE;Ingram,RH
在马萨诸塞州的东波士顿，对134名成人和213名儿童进行了非特异性支气管反应性评估，采用对冰点以下空气的正常呼吸过度。如果冷空气下1秒用力呼气量的减少除以初始肺活量大于9%，则认为存在反应性增加。男性和女性的支气管反应性相似，但儿童和年轻人（24岁及以下）比老年受试者更有可能成为反应者（p <0.001）。在过去的任何时候，医生诊断为哮喘的儿童（42.9%）是非哮喘儿童（19%）的两倍（p = 0.004）。92%（11/12）的当前活动性哮喘患者是应答者。然而，大部分无症状儿童的支气管反应性水平升高（18.9%）。这项横断面研究证明了在流行病学研究中测量非特异性支气管反应性的可行性，以及它与儿童年龄和喘息症状的关系。
Nonspecific bronchial responsiveness was assessed with eucapneic hyperpnea to subfreezing air in a population-based sample of 134 adults and 213 children in East Boston, Massachusetts. Increased responsiveness was considered to be present if the decrease in forced expiratory volume in one second with cold air divided by the initial vital capacity was greater than 9%. Men and women had similar bronchial responsiveness, but children and young adults (24 yr of age and younger) were significantly more likely to be responders than were older subjects (p < 0.001). Children with a doctor’s diagnosis of asthma at any time in the past were twice as likely (42.9%) to be responders as were nonasthmatic children (19%) (p = 0.004). Ninety-two percent (11/12) of currently active asthmatics were responders. However, a large percentage of asymptomatic children had increased levels of bronchial responsiveness (18.9%). This cross-sectional study demonstrates the feasibility of measurement of nonspecific bronchial responsiveness in epidemiologic studies, and its relationship to age and wheeze symptoms in children.