IN-VIVO SEROTONIN RELEASE AND LEARNED HELPLESSNESS
IN-VIVO SEROTONIN RELEASE AND LEARNED HELPLESSNESS
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DOI：
10.1016/0165-1781(94)90074-4
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发表时间：
1994-06-01
影响因子：
11.3
通讯作者：
JORDAN, S
中科院分区：
文献类型：
--
作者：
PETTY, F;KRAMER, G;JORDAN, S
习得性无助是一种因暴露于不可避免的压力而导致的行为抑郁，被认为是人类抑郁症的动物模型。与人类抑郁症一样，习得性无助与血清素功能缺陷有关，但这种关系的本质尚不完全清楚。我们使用体内微透析脑灌注来测量清醒、自由活动的大鼠内侧额叶皮层细胞外空间中的血清素（5-羟色胺，5HT）。在暴露于尾部电击应激之前灌注的大鼠的基础 5HT 水平本身与随后的习得性无助行为无关。然而，应激后5HT释放量显着增加，并伴有无助行为。这些数据支持这样的假设：皮质血清素过多与习得性无助的发展存在因果关系。
Learned helplessness, a behavioral depression caused by exposure to inescapable stress, is considered to be an animal model of human depressive disorder. Like human depression, learned helplessness has been associated with a defect in serotonergic function, but the nature of this relationship is not entirely clear. We have used in vivo microdialysis brain perfusion to measure serotonin (5-hydroxytryptamine, 5HT) in extracellular space of medial frontal cortex in conscious, freely moving rats. Basal 5HT levels in rats perfused before exposure to tail-shock stress did not themselves correlate with subsequent learned helplessness behavior. However, 5HT release after stress showed a significant increase with helpless behavior. These data support the hypothesis that a cortical seretonergic excess is causally related to the development of learned helplessness.